Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arpc1b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARPC1B |
| Full Name | Actin Related Protein Complex 1 Subunit B |
| Chromosome | 7q22.1 |
| Protein Type | Gene |
| Function | The complex associates with the side of an existing actin filament (mother filament), bringing Arp2 and Arp3 into proximity to form a new filament nucleus. |
| Primary Expression | immune cells, where it regulates actin-dependent processes including cell migration, phagocytosis, and immune synapse formation |
| Molecular Weight | 42 kDa |
| Amino Acids | 372 aa |
| GeneCards | ARPC1B |
| Human Protein Atlas | ARPC1B |
| Saddle-shaped structure | ARPC1B adopts a unique saddle-like fold that mediates interactions with other complex subunits |
| Binding interfaces | Provides binding sites for ARPC2 and ARPC3, contributing to complex stability |
| NPF binding site | Contains the primary binding site for nucleation-promoting factors like WASP |
| Actin-binding region | Interacts with actin monomers and filament sides |
| Complex assembly domain | Mediates assembly of the Arp2/3 complex |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arpc1b gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARPC1B | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARPC1B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning arpc1b in their description or question text
No additional research found