| Gene Symbol | ARPC1B |
| Full Name | Actin Related Protein Complex 1 Subunit B |
| Chromosome | 7q22.1 |
| Protein Type | Gene |
| Function | The complex associates with the side of an existing actin filament (mother filament), bringing Arp2 and Arp3 into proximity to form a new filament nucleus. |
| Primary Expression | immune cells, where it regulates actin-dependent processes including cell migration, phagocytosis, and immune synapse formation |
| Molecular Weight | 42 kDa |
| Amino Acids | 372 aa |
| GeneCards | ARPC1B |
| Human Protein Atlas | ARPC1B |
| Saddle-shaped structure | ARPC1B adopts a unique saddle-like fold that mediates interactions with other complex subunits |
| Binding interfaces | Provides binding sites for ARPC2 and ARPC3, contributing to complex stability |
| NPF binding site | Contains the primary binding site for nucleation-promoting factors like WASP |
| Actin-binding region | Interacts with actin monomers and filament sides |
| Complex assembly domain | Mediates assembly of the Arp2/3 complex |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!