Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATAC-seq accessibility: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| cell-type composition shifts | biomarker_for | mechanism | 0.70 |
| senescence stratification | biomarker_for | process | 0.70 |
| causal versus compensatory states | regulates | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| senescence stratification | modulates | process | 0.70 |
| senescence | causes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ATAC-seq accessibility separates causal from compensatory st | 0.342 | neurodegeneration | Are DNA methylation changes in neurodege |
| ATAC-seq accessibility separates causal from compensatory st | 0.327 | neurodegeneration | Are age-related DNA methylation changes |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.344
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.345
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Chromatin accessibility profiling by ATAC-seq. [PMID:35478247] | Grandi Fiorella C; Modi Hailey; Kampman | Nature protocols | 2022 | 0 |
| Chromatin accessibility profiling by ATAC-seq. [PMID:35478247] | Unknown | Nature protocols | 2022 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899] | Merlo, Cuchillo-Ibañez, Parlato, Ra | Neural plasticity | 2018 | 0 |
| An improved ATAC-seq protocol reduces background and enables interrogation of fr [PMID:28846090] | Corces M Ryan; Trevino Alexandro E; Hami | Nature methods | 2017 | 0 |
| An improved ATAC-seq protocol reduces background and enables interrogation of fr [PMID:28846090] | Unknown | Nature methods | 2017 | 0 |
| ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. [PMID:25559105] | Buenrostro, Wu, Chang, Greenleaf | Current protocols in molecular | 2016 | 0 |
| ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. [PMID:25559105] | Unknown | Current protocols in molecular | 2016 | 0 |
| DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899] | Unknown | Neural Plast | 2016 | 0 |
| Single-cell chromatin accessibility reveals principles of regulatory variation. [PMID:26083756] | Unknown | Nature | 2015 | 0 |
| Single-cell chromatin accessibility reveals principles of regulatory variation. [PMID:26083756] | Buenrostro, Wu, Litzenburger, Ruff, Gonz | Nature | 2015 | 0 |
| Human endogenous retrovirus-K contributes to motor neuron disease. [PMID:26424568] | Li W, Lee MH, Henderson L, Tyagi R, Bach | Science translational medicine | 2015 | 0 |
| Human endogenous retrovirus-K contributes to motor neuron disease. [PMID:26424568] | Li W, Lee MH, Henderson L, Tyagi R, Bach | Science translational medicine | 2015 | 0 |
| Transposition of native chromatin for fast and sensitive epigenomic profiling of [PMID:24097267] | Buenrostro, Giresi, Zaba, Chang, Greenle | Nature methods | 2014 | 0 |
| DNA damage and its links to neurodegeneration. [PMID:25033177] | Madabhushi, Pan, Tsai | Neuron | 2014 | 0 |
| DNA damage and its links to neurodegeneration. [PMID:25033177] | Unknown | Neuron | 2014 | 0 |
| Transposition of native chromatin for fast and sensitive epigenomic profiling of [PMID:24097267] | Buenrostro Jason D; Giresi Paul G; Zaba | Nature methods | 2013 | 0 |
| DNA repair deficiency and neurodegeneration. [PMID:17700067] | Unknown | Cell cycle (Georgetown, Tex.) | 2007 | 0 |
| DNA repair deficiency and neurodegeneration. [PMID:17700067] | Katyal, McKinnon | Cell cycle (Georgetown, Tex.) | 2007 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 3 · Score: 0.75 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
Hypotheses and analyses mentioning ATAC-seq accessibility in their description or question text
No additional research found