biological_process

senescence

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about senescence: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2624Connections

11Hypotheses

9Analyses

39Outgoing

50Incoming

Summary

senescence is an entity related to neurodegeneration research. Key relationships include: inhibits, regulates, activates. Associated with neurodegeneration, organ fibrosis. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Biological Process Info

Name	Cellular Senescence in Neurodegeneration
Category	stub, redirect
Key Genes/Proteins	P53, IL-4, p53, PPARGC1A
Related Diseases	chronic kidney disease, cancer, defective autophagy
Linked Hypotheses	11 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Stress["Cellular Stress"] -->|"Triggers"| Arrest["Cell Cycle Arrest"]
    Arrest -->|"Irreversible"| Senescence["Senescent State"]
    Senescence -->|"Secretes"| SASP["Senescence-Associated Secretory Phenotype"]
    SASP -->|"Releases"| Factors["Cytokines, Proteases, ROS"]
    Factors -->|"Induce"| Inflammation["Chronic Inflammation"]
    Factors -->|"Cause"| Bystander["Bystander Senescence"]
    Senescence -->|"Accumulates with"| Aging["Aging"]
    SASP -.Contributes to.-> Dysfunction["Tissue Dysfunction"]
    Dysfunction -.Linked to.-> AD["Alzheimer's Disease"]

Outgoing (607)

Target	Relation	Type	Str
SASP	causes	process	0.95
aging	promotes	process	0.95
cell-cycle arrest	causes	process	0.95
hypersecretory state	causes	process	0.95
chronic kidney disease	associated_with	disease	0.95
kidney aging	regulates	process	0.92
cancer	associated_with	disease	0.90
aging	downstream_of	process	0.88
cancer	prevents	disease	0.87
skin photoaging	associated_with	disease	0.85
cardiovascular diseases	causes	disease	0.85
adaptive responses	inhibits	process	0.85
senescence-associated disease	causes	disease	0.85
chronic disease	associated_with	disease	0.85
neurodegeneration	contributes_to	disease	0.80
structural deterioration	causes	phenotype	0.80
tissue repair	promotes	process	0.80
glioma	promotes	disease	0.80
autophagy	modulates	process	0.80
glioma recurrence	associated_with	phenotype	0.75
organ fibrosis	associated_with	disease	0.70
TREM2	activates	gene	0.60
SIRT1	activates	gene	0.60
SIRT6	activates	gene	0.55
SIRT6	co_mentioned	gene	0.55
TERT	activates	gene	0.55
TREM2	binds_to	gene	0.55
TREM2	associated_with	gene	0.55
TREM2	regulates	gene	0.55
SYK	activates	gene	0.55
TFR1	debate_co_mention	gene	0.45
SLC7A11	debate_co_mention	gene	0.45
STING1	debate_co_mention	gene	0.45
SIRT6	debate_co_mention	gene	0.45
TET2	debate_co_mention	gene	0.45
SIRT1	debate_co_mention	gene	0.45
TFEB	debate_co_mention	gene	0.45
TREM2	debate_co_mention	gene	0.45
TREM2	co_mentioned	gene	0.40

Incoming (2017)

Source	Relation	Type	Str
P53	regulates	gene	0.95
ROS	promotes	process	0.95
Ginkgetin	inhibits	drug	0.95
IL-4	prevents	protein	0.95
p53	regulates	gene	0.95
stress	triggers	process	0.95
PPARGC1A	inhibits	protein	0.90
defective autophagy	causes	phenotype	0.90
TP53	regulates	gene	0.90
SQSTM1	regulates	protein	0.90
cytotoxic chemotherapy	promotes	drug	0.90
inflammaging	associated_with	process	0.90
chronic inflammation	promotes	process	0.90
pro-inflammatory signaling	drives	pathway	0.90
DNA	participates_in	gene	0.90
SRT2104	protects_against	drug	0.90
TGF	participates_in	gene	0.90
p16INK4a	activates	gene	0.85
NFE2L2	regulates	gene	0.85
MTOR	regulates	gene	0.85
TGFB1	regulates	gene	0.85
IGF1	regulates	gene	0.85
AKT1	regulates	gene	0.85
cGAS-STING pathway	regulates	pathway	0.85
nutrient sensing	regulates	pathway	0.85
cGAS-STING signaling	associated_with	pathway	0.85
mitochondrial dysfunction	promotes	process	0.85
microglia	active_in	cell_type	0.85
DAM microglia	active_in	cell_type	0.85
IL-6	participates_in	gene	0.85
astrocytes	active_in	cell_type	0.85
mitochondrial biogenesis	suppresses	process	0.85
epigenetic regulation	regulates	process	0.82
SQSTM1	inhibits	protein	0.80
autophagy	inhibits	pathway	0.80
p21	activates	gene	0.80
Tinospora cordifolia	prevents	drug	0.80
oxidative stress	promotes	process	0.80
inflammation	promotes	process	0.80
NAD	participates_in	gene	0.80
ROS	participates_in	gene	0.80
RNA	participates_in	gene	0.80
TREM2	participates_in	gene	0.80
cellular aging	mediates	process	0.80
ABCA1	participates_in	gene	0.80
cAMP signaling	modulates	pathway	0.75
TNF	participates_in	gene	0.75
neurons	active_in	cell_type	0.75
BCL-2	participates_in	gene	0.75
APP	participates_in	gene	0.75

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.612	neurodegeneration	Gene expression changes in aging mouse b
Senescence-Activated NAD+ Depletion Rescue	0.604	neurodegeneration	Senolytic therapy for age-related neurod
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.587	neurodegeneration	Gene expression changes in aging mouse b

TREM2-Mediated Cholesterol Dysregulation in Microglial Senes	0.574	neurodegeneration	Gene expression changes in aging mouse b
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Senescence-Induced Lipid Peroxidation Spreading	0.533	neurodegeneration	Senolytic therapy for age-related neurod
Senescence-Associated Myelin Lipid Remodeling	0.511	neurodegeneration	Senolytic therapy for age-related neurod
cGAS-STING Senescence Circuit Disruption	0.486	neurodegeneration	Gene expression changes in aging mouse b
Senescence-Tau Decoupling Therapy	0.410	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (9)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotyp [PMID:38816399]	Gao Z, Guo X, Sun Z, Wu S, Wang Q, Huang	Schizophrenia (Heidelb)	2024	1
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317]	Velma GR, Krider IS, Alves ETM, Courey J	J Med Chem	2024	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409]	Navas LE, Carnero A	Signal Transduct Target Ther	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980]	Gerner RR, Klepsch V, Macheiner S, Arnha	Gut	2018	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
NAD+ and sirtuins in aging and disease. [PMID:24786309]	Imai S, Guarente L	Trends Cell Biol	2014	1
Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: [PMID:21098459]	Mallat Z, Lambeau G, Tedgui A	Circulation	2010	1
Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin prod [PMID:18811942]	Godkin JD, Roberts MP, Elgayyar M, Guan	Reprod Biol Endocrinol	2008	1
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793]	["Wang R", "Feng Y", "Zhou Z", "Jiang J"	Frontiers in aging neuroscienc	2026	0
Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182]	["Puerta R", "Garc\u00eda-Gonz\u00e1lez	medRxiv : the preprint server	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0

senescence

Understanding Entity Pages

Summary

Wiki Pages (21)

Cellular Senescence in Neurodegeneration

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Pathway Diagram

Outgoing (607)

Incoming (2017)

Targeting Hypotheses (11)

Mentioning Analyses (9)

What is the temporal sequence of TREM2 signaling transition from protective to i

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does pericyte senescence mechanistically promote glioma cell growth and inva

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Can metabolic interventions truly reverse established cellular senescence or onl

What is the optimal therapeutic window timing for autophagy enhancement versus s

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Related Papers (20)

senescence

Understanding Entity Pages

Summary

Wiki Pages (21)

Cellular Senescence in Neurodegeneration

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Device Therapies Comparison for CBS/PSP

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

TREM2 Mechanism Hub

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes

APOC4 — Apolipoprotein C-IV

Pathway Diagram

Outgoing (607)

Incoming (2017)

Targeting Hypotheses (11)

Mentioning Analyses (9)

What is the temporal sequence of TREM2 signaling transition from protective to i

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does pericyte senescence mechanistically promote glioma cell growth and inva

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Can metabolic interventions truly reverse established cellular senescence or onl

What is the optimal therapeutic window timing for autophagy enhancement versus s

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

How can senescent microglia be molecularly distinguished from beneficial activat

Senescent cell clearance as neurodegeneration therapy

Related Papers (20)