Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATAXIN10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | ATAXIN10 |
| Full Name | Ataxin-10 |
| Chromosome | 22q13.31. |
| Protein Family | Ataxin family (non-aggregating) |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | High in cerebellum (Purkinje cells), cerebral cortex, brainstem |
| Subcellular Localization | and export signals for nucleocytoplasmic shuttling - **No known catalytic domain |
| Molecular Weight | ~47 kDa (420 amino acids) |
| Amino Acids | 420 aa |
| UniProt ID | Q9UBB6 |
| GeneCards | ATAXIN10 |
| Human Protein Atlas | ATAXIN10 |
| HEAT repeats | 6-7 HEAT (Huntingtin, Elongation factor 3, PP2A, TOR1) repeat motifs throughout the protein |
| Alpha-helical content | Predominantly alpha-helical secondary structure |
| NLS/NES sequences | Nuclear localization and export signals for nucleocytoplasmic shuttling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATAXIN10["ATAXIN10 Protein"]
SCA10["Spinocerebellar Ataxia Type 10"]
ATTCT_repeat["ATTCT Pentanucleotide Repeat"]
RNA_toxicity["RNA Toxicity"]
Splicing_defects["Splicing Defects"]
Purkinje_cells["Purkinje Cell Dysfunction"]
Cerebellar_atrophy["Cerebellar Atrophy"]
Motor_symptoms["Motor Ataxia"]
Seizures["Epileptic Seizures"]
DNA_repair["DNA Repair Pathways"]
Oxidative_stress["Oxidative Stress"]
Mitochondrial_dysfunction["Mitochondrial Dysfunction"]
Neuroinflammation["Neuroinflammation"]
Cell_death["Neuronal Cell Death"]
ATTCT_repeat -->|"expands"| ATAXIN10
ATAXIN10 -->|"causes"| SCA10
ATAXIN10 -->|"produces toxic"| RNA_toxicity
RNA_toxicity -->|"disrupts"| Splicing_defects
ATAXIN10 -->|"impairs"| DNA_repair
DNA_repair -->|"increases"| Oxidative_stress
Oxidative_stress -->|"damages"| Mitochondrial_dysfunction
Mitochondrial_dysfunction -->|"triggers"| Neuroinflammation
ATAXIN10 -->|"damages"| Purkinje_cells
Purkinje_cells -->|"leads to"| Cerebellar_atrophy
Cerebellar_atrophy -->|"causes"| Motor_symptoms
SCA10 -->|"presents with"| Seizures
Neuroinflammation -->|"promotes"| Cell_death
classDef central fill:#1a3a4a,stroke:#4fc3f7,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,color:#fff
class ATAXIN10 central
class RNA_toxicity,Splicing_defects,Oxidative_stress,Mitochondrial_dysfunction,Neuroinflammation,Purkinje_cells,Cerebellar_atrophy,Cell_death pathological
class DNA_repair protective
class SCA10,Motor_symptoms,Seizures,ATTCT_repeat disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATAXIN10 in their description or question text
No additional research found