protein

ATAXIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATAXIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	ATAXIN2
Protein Family	Ataxin-2 family, RNA-binding proteins
Function	is a cytoplasmic RNA-binding protein encoded by the ATXN2 gene that plays critical roles in RNA metabolism, stress granule dynamics, and translational control.
Molecular Weight	140 kDa
Amino Acids	1313 aa
UniProt ID	Q99700
GeneCards	ATAXIN2
Human Protein Atlas	ATAXIN2
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATAXIN2 — AlphaFold Q99700 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ataxin-2

protein · 1677 words

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Pathway Diagram

graph TD
    ATAXIN2["ATAXIN2 protein"]
    PolyQ["Polyglutamine expansion"]
    Aggregates["Protein aggregates"]
    SCA2["Spinocerebellar ataxia type 2"]
    ALS["Amyotrophic lateral sclerosis"]
    RNA_binding["RNA binding function"]
    Stress_granules["Stress granule formation"]
    TDP43["TDP-43 protein"]
    Translation["Protein translation"]
    Autophagy["Autophagy pathway"]
    Cerebellar["Cerebellar degeneration"]
    Motor_neurons["Motor neuron death"]
    Cell_death["Neuronal cell death"]
    Mitochondria["Mitochondrial dysfunction"]
    ER_stress["ER stress response"]

    PolyQ -->|"causes"| ATAXIN2
    ATAXIN2 -->|"forms"| Aggregates
    ATAXIN2 -->|"causes"| SCA2
    ATAXIN2 -->|"increases risk"| ALS
    ATAXIN2 -->|"regulates"| RNA_binding
    ATAXIN2 -->|"modulates"| Stress_granules
    ATAXIN2 -->|"interacts with"| TDP43
    RNA_binding -->|"controls"| Translation
    Aggregates -->|"impairs"| Autophagy
    SCA2 -->|"leads to"| Cerebellar
    ALS -->|"causes"| Motor_neurons
    Cerebellar -->|"results in"| Cell_death
    Motor_neurons -->|"triggers"| Cell_death
    Aggregates -->|"induces"| Mitochondria
    Aggregates -->|"activates"| ER_stress

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class ATAXIN2 central
    class Autophagy,Translation protective
    class Aggregates,Cell_death,Cerebellar,Motor_neurons,Mitochondria,ER_stress pathological
    class RNA_binding,Stress_granules,TDP43 regulatory
    class SCA2,ALS,PolyQ disease

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ATAXIN2 in their description or question text

No additional research found