protein 1,677 words KG: ATAXIN2 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

Ataxin-2

🔬 Protein Info
Gene SymbolATAXIN2
Protein FamilyAtaxin-2 family, RNA-binding proteins
Functionis a cytoplasmic RNA-binding protein encoded by the ATXN2 gene that plays critical roles in RNA metabolism, stress granule dynamics, and translational control.
Subcellular LocalizationCytoplasm, stress granules, RNA processing bodies (P-bodies)
Molecular Weight140 kDa
Amino Acids1313 aa
UniProt IDQ99700
GeneCardsATAXIN2
Human Protein AtlasATAXIN2
GeneATXN2
PDBNo structures deposited
Mol. Weight140 kDa (1313 aa)
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
TARDBP Mutations in Amyotrophic Lateral Sclerosis
disease · Pages share 4 hypotheses
mitochondrial-dysfunction-neurodegeneration-comparison
disease · Pages share 4 hypotheses
Familial vs Sporadic Neurodegeneration Comparison
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses