Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about atg17a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATG17A |
| Full Name | Autophagy Related 17A |
| Chromosome | 2q37.2 |
| Function | is a critical autophagy protein that serves as a scaffold for the ULK1 complex, essential for autophagosome formation. |
| Primary Expression | Ubiquitous, high in brain |
| Molecular Weight | 177 kDa |
| Amino Acids | 1594 aa |
| Pathways | PI3K |
| UniProt ID | [Q8N5N7](https://www.uniprot.org/uniprot/Q8N5N7) |
| Ensembl ID | ENSG00000155089 |
| OMIM | 604501 |
| GeneCards | ATG17A |
| Human Protein Atlas | ATG17A |
| N-terminal coiled-coil domains | Mediate self-association and interaction with ULK1 |
| Central LC3-interacting region (LIR) | Allows binding to ATG8 family proteins (LC3/GABARAP) |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["atg17a gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ATG17A | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ATG17A | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning atg17a in their description or question text
No additional research found