ATP10B

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP10B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

ATP10B is a phospholipid flippase associated with Parkinson's disease and dementia with Lewy bodies

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graph TD
    ATP10B["ATP10B
(P4-ATPase)"]
    PS_asymmetry["Phosphatidylserine
Asymmetry"]
    membrane_integrity["Membrane
Integrity"]
    lipid_transport["Lipid Transport
Across Membranes"]
    ATP_hydrolysis["ATP Hydrolysis"]
    cellular_energy["Cellular Energy
Depletion"]
    membrane_disruption["Membrane
Disruption"]
    PS_externalization["PS Externalization"]
    apoptotic_signaling["Apoptotic
Signaling"]
    neuronal_death["Neuronal
Death"]
    neurodegeneration["Neurodegeneration"]
    synaptic_dysfunction["Synaptic
Dysfunction"]
    calcium_dysregulation["Calcium
Dysregulation"]
    oxidative_stress["Oxidative
Stress"]

    ATP10B -->|"maintains"| PS_asymmetry
    ATP10B -->|"requires"| ATP_hydrolysis
    ATP10B -->|"facilitates"| lipid_transport
    PS_asymmetry -->|"preserves"| membrane_integrity
    ATP_hydrolysis -->|"depletes"| cellular_energy
    lipid_transport -->|"maintains"| membrane_integrity
    membrane_integrity -->|"loss leads to"| membrane_disruption
    membrane_disruption -->|"causes"| PS_externalization
    membrane_disruption -->|"triggers"| calcium_dysregulation
    PS_externalization -->|"activates"| apoptotic_signaling
    calcium_dysregulation -->|"induces"| oxidative_stress
    apoptotic_signaling -->|"promotes"| neuronal_death
    oxidative_stress -->|"accelerates"| neuronal_death
    neuronal_death -->|"leads to"| neurodegeneration
    membrane_disruption -->|"impairs"| synaptic_dysfunction
    synaptic_dysfunction -->|"contributes to"| neurodegeneration

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class ATP10B central
    class PS_asymmetry,membrane_integrity,lipid_transport protective
    class membrane_disruption,PS_externalization,apoptotic_signaling,neuronal_death,cellular_energy,calcium_dysregulation,oxidative_stress,synaptic_dysfunction pathological
    class ATP_hydrolysis regulatory
    class neurodegeneration disease

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