disease

Parkinson's disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Parkinson's disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7018Connections

0Hypotheses

9Analyses

50Outgoing

50Incoming

Summary

Parkinson's disease is a disease characterized by neurodegeneration research. Key relationships include: associated with, treats, causes. Associated with Traumatic brain injury, cirrhosis, colon adenocarcinoma. Connected to 195 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	α-synuclein, p38, PRKN, α-Synuclein, TAL1, PINK1, respiratory chain complex I, alpha-synuclein
Therapeutic Agents	phytochemicals, Dopa-EVs, QBA, Ginsenoside Rg1, Ginsenoside Rb1, GLP-1RAs
KG Connections	1250 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Parkinson_s_disease["Parkinson's disease"] -->|"causes"| dopaminergic_neurons["dopaminergic neurons"]
    Parkinson_s_disease["Parkinson's disease"] -->|"associated"| nigrostriatal_axons["nigrostriatal axons"]
    Parkinson_s_disease["Parkinson's disease"] -->|"associated"| substantia_nigra["substantia nigra"]
    Parkinson_s_disease["Parkinson's disease"] -->|"associated"| oxidative_stress["oxidative stress"]
    Parkinson_s_disease["Parkinson's disease"] -->|"causes"| dopaminergic_neuron_loss["dopaminergic neuron loss"]
    Parkinson_s_disease["Parkinson's disease"] -->|"associated"| gut_microbiota["gut microbiota"]
    PINK1["PINK1"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    SNCA["SNCA"] -->|"causes"| Parkinson_s_disease["Parkinson's disease"]
    GBA["GBA"] -->|"increases risk"| Parkinson_s_disease["Parkinson's disease"]
    lysosomal_storage_disorder_gen["lysosomal storage disorder gene variants"] -->|"increases risk"| Parkinson_s_disease["Parkinson's disease"]
    style Parkinson_s_disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2873)

Target	Relation	Type	Str
cerebellum	affects	brain_region	0.90
microglia	affects	cell_type	0.90
substantia nigra	affects	brain_region	0.90
neurons	affects	cell_type	0.90
dopaminergic neurons	affects	cell_type	0.90
striatum	affects	brain_region	0.90
unfolded protein response	involves	pathway	0.90
astrocytes	affects	cell_type	0.90
mitochondrial function	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
gait velocity	causes	phenotype	0.90
stride length	causes	phenotype	0.90
gait variability	causes	phenotype	0.85
necroptosis	involves	pathway	0.80
spinal cord	affects	brain_region	0.80
lipid metabolism	involves	pathway	0.80
oligodendrocytes	affects	cell_type	0.80
pyroptosis	involves	pathway	0.80
ferroptosis	involves	pathway	0.80
blood-brain barrier	affects	brain_region	0.80
DEPRESSION	comorbid_with	disease	0.80
olfactory bulb	affects	brain_region	0.80
temporal lobe	affects	brain_region	0.80
cGAS-STING	involves	pathway	0.80
dopamine receptor	involves	receptor	0.80
balance control	associated_with	phenotype	0.80
task prioritization toward vocal output	drives	phenotype	0.80
dopaminergic neurons	causes	cell_type	0.70
nigrostriatal axons	associated_with	cell_type	0.70
substantia nigra	associated_with	brain_region	0.70
oxidative stress	associated_with	process	0.70
dopaminergic neuron loss	causes	process	0.70
gut microbiota	associated_with	pathway	0.70
mitophagy	associated_with	process	0.70
autophagy pathway	involves	pathway	0.70
AMPK signaling	involves	pathway	0.70
cortex	affects	brain_region	0.70
T cells	affects	cell_type	0.70
TGF-beta signaling	involves	pathway	0.70
thalamus	affects	brain_region	0.70
PI3K-AKT-mTOR signaling	involves	pathway	0.70
locus coeruleus	affects	brain_region	0.70
mitochondrial dynamics	involves	pathway	0.70
basal ganglia	affects	brain_region	0.70
brainstem	affects	brain_region	0.70
epigenetic regulation	involves	pathway	0.70
axon	disrupts	organelle	0.70
muscarinic receptor	involves	receptor	0.70
hippocampus	affects	brain_region	0.70
blood-brain barrier	involves	pathway	0.70

Incoming (4145)

Source	Relation	Type	Str
PINK1	risk_factor_for	gene	0.95
USP25	risk_factor_for	gene	0.95
Α-SYNUCLEIN	contributes_to	protein	0.95
G2019S LRRK2 VARIANT	risk_factor_for	protein	0.95
VPS35	risk_factor_for	gene	0.95
Manganese	causes	drug	0.92
PSAP-GPR37-IL-6 axis	therapeutic_target	pathway	0.92
iron homeostasis	associated_with	process	0.92
cGAS-STING-YY1-LCN2	associated_with	pathway	0.92
FGF21	protects_against	protein	0.92
dysfunctional mitochondria	associated_with	phenotype	0.92
PINK1	associated_with	gene	0.90
SNCA	causes	gene	0.90
GBA	contributes_to	gene	0.90
lysosomal storage disorder gene variants	contributes_to	gene	0.90
PARKIN	associated_with	gene	0.90
dopamine neurons	associated_with	cell_type	0.90
MPTP	causes	drug	0.90
CLEC7A	associated_with	gene	0.90
STING	contributes_to	protein	0.90
impaired mitophagy	promotes	phenotype	0.90
MTOR	therapeutic_target	protein	0.90
NOTCH2NLC	risk_factor_for	gene	0.90
astrocyte senescence	promotes	process	0.90
USP25	therapeutic_target	gene	0.90
ALS	activates	gene	0.90
ALS	associated_with	gene	0.90
LRRK2	activates	gene	0.90
ALS	implicated_in	gene	0.90
LRRK2	regulates	gene	0.90
OXIDATIVE STRESS	central_in	process	0.90
SIRT1	alleviates	gene	0.90
PKM2	worsens	protein	0.90
GBA	risk_factor	gene	0.90
α-synuclein aggregation	contributes_to	process	0.90
GLUCOCEREBROSIDASE	associated_with	protein	0.90
GBA1 mutations	risk_factor_for	biomarker	0.90
Montelukast	protects_against	drug	0.90
NME3	involved_in	protein	0.90
PINK1	therapeutic_target	gene	0.88
IRP2	risk_factor_for	protein	0.88
RAS dysregulation	promotes	phenotype	0.88
LNK	associated_with	protein	0.88
ferroptosis	promotes	process	0.87
RB5	treats	drug	0.87
AMPK	therapeutic_target	protein	0.85
dysregulation of AMPK/SIRT1/PGC-1α	promotes	process	0.85
STING	associated_with	protein	0.85
STING	therapeutic_target	protein	0.85
GFAP	biomarker_for	protein	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (9)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Parkinson's disease

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Pathway Diagram

Outgoing (2873)

Incoming (4145)

Targeting Hypotheses (0)

Mentioning Analyses (9)

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

CRISPR-based therapeutic approaches for neurodegenerative diseases

GBA-Synuclein Loop Therapeutics for PD

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (0)

Parkinson's disease

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index