ATP13A3

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP13A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

ATP13A3 encodes a P5-type ATPase (ATP13A3/P5-ATPase) that functions as a cation transporter with specificity for calcium and other divalent cations. ATP13A3 is closely related to ATP13A2 (PARK9), and variants are associated with Parkinson's disease and pulmonary hypertension.

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graph TD
    ATP13A3["ATP13A3
(P5-type ATPase)"]
    
    ATP13A3 -->|"transports"| polyamines["Polyamine Transport
(spermidine, spermine)"]
    ATP13A3 -->|"maintains"| lysosomal_pH["Lysosomal pH
Homeostasis"]
    ATP13A3 -->|"regulates"| autophagy["Autophagy
Process"]
    
    polyamines -->|"supports"| protein_folding["Protein Folding
Quality Control"]
    polyamines -->|"protects"| mitochondria["Mitochondrial
Function"]
    
    lysosomal_pH -->|"enables"| enzyme_activity["Lysosomal Enzyme
Activity"]
    lysosomal_pH -->|"facilitates"| protein_degradation["Protein
Degradation"]
    
    autophagy -->|"clears"| misfolded_proteins["Misfolded Protein
Clearance"]
    autophagy -->|"removes"| damaged_organelles["Damaged Organelle
Removal"]
    
    ATP13A3_dysfunction["ATP13A3
Dysfunction"] -->|"impairs"| ATP13A3
    ATP13A3_dysfunction -->|"leads to"| lysosomal_dysfunction["Lysosomal
Dysfunction"]
    ATP13A3_dysfunction -->|"causes"| polyamine_imbalance["Polyamine
Imbalance"]
    
    lysosomal_dysfunction -->|"contributes to"| neurodegeneration["Neurodegeneration"]
    polyamine_imbalance -->|"promotes"| oxidative_stress["Oxidative
Stress"]
    oxidative_stress -->|"accelerates"| neurodegeneration
    
    misfolded_proteins -->|"accumulate in"| neurodegeneration
    
    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff
    
    class ATP13A3 central
    class polyamines,protein_folding,mitochondria,enzyme_activity,protein_degradation,autophagy,misfolded_proteins,damaged_organelles protective
    class ATP13A3_dysfunction,lysosomal_dysfunction,polyamine_imbalance,oxidative_stress pathological
    class lysosomal_pH regulatory
    class neurodegeneration disease

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