Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP13A9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATP13A9 is a P5B-type ATPase gene linked to Parkinson's disease risk through GWAS studies. This page covers its structure, function, and therapeutic implications.
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| Gene Symbol | ATP13A9 |
| Full Name | ATPase cation transporting 13A9 |
| Aliases | Page for ATP13A9 Protein |
| Chromosome | 3q29 |
| Protein Family | P5B-type ATPase |
| Function | Lysosomal Zn²⁺ transport? |
| Primary Expression | multiple regions[@usenovic2012]: |
| Subcellular Localization | the endoplasmic reticulum (ER) and lysosomal compartments, where it likely participates in cation homeostasis and intrac |
| Molecular Weight | 140 kDa |
| UniProt ID | Q6ZVN8 |
| NCBI Gene ID | 79676 |
| Ensembl ID | ENSG00000165672 |
| OMIM | 617879 |
| GeneCards | ATP13A9 |
| Human Protein Atlas | ATP13A9 |
| Associated Diseases | Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATP13A9["ATP13A9
P5A-type ATPase"]
ATP13A9 -->|"encodes"| ATP13A9_protein["ATP13A9 Protein
P5A-type ATPase"]
ATP13A9_protein -->|"maintains"| lipid_homeostasis["Lipid Homeostasis"]
ATP13A9_protein -->|"regulates"| membrane_integrity["Membrane Integrity"]
ATP13A9_protein -->|"transports"| metal_ions["Metal Ion Transport
Zn2+, Mn2+"]
ATP13A9_mutation["ATP13A9 Mutations"] -->|"causes"| protein_dysfunction["Protein Dysfunction"]
protein_dysfunction -->|"disrupts"| lipid_homeostasis
protein_dysfunction -->|"impairs"| metal_ions
lipid_homeostasis -->|"loss leads to"| membrane_damage["Membrane Damage"]
metal_ions -->|"dysregulation causes"| oxidative_stress["Oxidative Stress"]
membrane_damage -->|"triggers"| neuronal_dysfunction["Neuronal Dysfunction"]
oxidative_stress -->|"induces"| neuronal_dysfunction
neuronal_dysfunction -->|"leads to"| neurodegeneration["Neurodegeneration"]
mitochondrial_stress["Mitochondrial Stress"] -->|"contributes to"| neurodegeneration
oxidative_stress -->|"damages"| mitochondrial_stress
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class ATP13A9 central
class lipid_homeostasis,membrane_integrity,metal_ions protective
class ATP13A9_mutation,protein_dysfunction,membrane_damage,oxidative_stress,neuronal_dysfunction,mitochondrial_stress pathological
class ATP13A9_protein regulatory
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATP13A9 in their description or question text
No additional research found