gene

ATP2B2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ATP2B2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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0Incoming

0Experiments

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Summary

ATP2B2 Gene

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🧬 Gene Info

Gene Symbol	ATP2B2
Full Name	ATPase Plasma Membrane Ca2+ Transporting 2
Chromosome	3p25.3
Protein Type	Transporter
Function	ATP2B2 (PMCA2) is a plasma membrane calcium ATPase important for auditory function and synaptic plasticity.
Primary Expression	the inner ear and brain
Subcellular Localization	the plasma membrane and interacts with calmodulin, which acts as a regulatory cofactor. Calmodulin binding increases the
UniProt ID	[Q9UQC2](https://www.uniprot.org/uniprotkb/Q9UQC2/entry)
GeneCards	ATP2B2
Human Protein Atlas	ATP2B2
ATP2A	Sarcoplasmic reticulum calcium ATPase genes involved in calcium signaling
CALMODULIN	Key regulatory protein for PMCA2 activation
SLC8A3	Sodium-calcium exchanger contributing to neuronal calcium homeostasis
Calcium Dysregulation	Central pathology in multiple neurodegenerative diseases
Associated Diseases	Deafness, cerebellar ataxia
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATP2B2 Gene

gene · 629 words

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Pathway Diagram

graph TD
    ATP2B2["ATP2B2
(PMCA2 gene)"]
    PMCA2["PMCA2 protein
(plasma membrane Ca-ATPase 2)"]
    Ca_influx["Calcium influx
(NMDA, VGCC)"]
    Ca_cytosol["Cytosolic Ca2+
elevation"]
    Ca_extrusion["Calcium extrusion
from cell"]
    Ca_homeostasis["Calcium homeostasis
maintenance"]
    Excitotoxicity["Excitotoxicity"]
    Mitochondrial_damage["Mitochondrial
dysfunction"]
    Calpain_activation["Calpain
activation"]
    Synaptic_dysfunction["Synaptic
dysfunction"]
    Neurodegeneration["Neurodegeneration"]
    AD["Alzheimer's
disease"]
    PD["Parkinson's
disease"]
    ALS["Amyotrophic lateral
sclerosis"]
    Aging["Cellular aging
processes"]

    ATP2B2 -->|"encodes"| PMCA2
    Ca_influx -->|"increases"| Ca_cytosol
    PMCA2 -->|"pumps out"| Ca_extrusion
    Ca_extrusion -->|"maintains"| Ca_homeostasis
    Ca_cytosol -->|"triggers"| Excitotoxicity
    Ca_cytosol -->|"damages"| Mitochondrial_damage
    Ca_cytosol -->|"activates"| Calpain_activation
    Excitotoxicity -->|"impairs"| Synaptic_dysfunction
    Mitochondrial_damage -->|"promotes"| Neurodegeneration
    Calpain_activation -->|"promotes"| Neurodegeneration
    Synaptic_dysfunction -->|"leads to"| Neurodegeneration
    Aging -->|"reduces"| PMCA2
    Neurodegeneration -->|"manifests in"| AD
    Neurodegeneration -->|"manifests in"| PD
    Neurodegeneration -->|"manifests in"| ALS

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff

    class ATP2B2,PMCA2 central
    class Ca_extrusion,Ca_homeostasis protective
    class Ca_cytosol,Excitotoxicity,Mitochondrial_damage,Calpain_activation,Synaptic_dysfunction,Neurodegeneration pathological
    class Ca_influx,Aging regulatory
    class AD,PD,ALS disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

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Related Research

Hypotheses and analyses mentioning ATP2B2 in their description or question text

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