Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP6V0A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATP6V0A1 |
| Chromosome | 17q21.31 [@forgac2007] |
| Protein Type | Enzyme |
| Function | ATP6V0A1 encodes the largest subunit of the V0 sector (a-subunit isoform a1), which forms the proton channel across the lysosomal membrane [3]. |
| Pathways | Role |
| UniProt ID | Q9Y282 |
| NCBI Gene ID | 271 |
| Ensembl ID | ENSG00000115884 |
| GeneCards | ATP6V0A1 |
| Human Protein Atlas | ATP6V0A1 |
| Lysosomal acidification | Maintaining optimal pH (~4.5-5.0) for hydrolytic enzyme activity |
| Synaptic vesicle acidification | Enabling neurotransmitter uptake into synaptic vesicles |
| Autophagosome-lysosome fusion | Regulating the final degradative step of autophagy |
| Endosomal trafficking | Facilitating protein sorting and recycling |
| Lysosomal dysfunction | Reduced V-ATPase activity impairs lysosomal degradation, leading to accumulation of alpha-synuclein aggregates |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATP6V0A1["ATP6V0A1
V-ATPase subunit"]
V_ATPase["V-ATPase Complex
Proton pump"]
Lysosome["Lysosomal Function
Acidification"]
Autophagy["Autophagy
Cellular clearance"]
Protein_Agg["Protein Aggregation
Misfolded proteins"]
Mitochondria["Mitochondrial Function
ATP synthesis"]
Endosome["Endosomal Trafficking
Vesicle transport"]
Synaptic["Synaptic Vesicles
Neurotransmission"]
Ca_Homeostasis["Calcium Homeostasis
Ion regulation"]
Neuroinflam["Neuroinflammation
Glial activation"]
Oxidative["Oxidative Stress
ROS damage"]
Neuronal_Death["Neuronal Death
Cell death"]
Neurodegeneration["Neurodegeneration
Disease progression"]
ATP6V0A1 -->|"encodes"| V_ATPase
V_ATPase -->|"maintains"| Lysosome
V_ATPase -->|"regulates"| Endosome
V_ATPase -->|"acidifies"| Synaptic
Lysosome -->|"promotes"| Autophagy
Autophagy -->|"clears"| Protein_Agg
Endosome -->|"affects"| Ca_Homeostasis
Synaptic -->|"maintains"| Mitochondria
Protein_Agg -->|"triggers"| Neuroinflam
Protein_Agg -->|"causes"| Oxidative
Neuroinflam -->|"promotes"| Neuronal_Death
Oxidative -->|"induces"| Neuronal_Death
Neuronal_Death -->|"leads to"| Neurodegeneration
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class ATP6V0A1 central
class V_ATPase,Lysosome,Autophagy,Mitochondria regulatory
class Endosome,Synaptic,Ca_Homeostasis protective
class Protein_Agg,Neuroinflam,Oxidative,Neuronal_Death pathological
class Neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATP6V0A1 in their description or question text
No additional research found