ATXN7

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ATXN7 — Ataxin-7

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graph TD
    ATXN7["ATXN7 gene"]
    PolyQ["Polyglutamine expansion"]
    MutATXN7["Mutant ATXN7 protein"]
    SAGA["SAGA chromatin complex"]
    SCA7["Spinocerebellar ataxia type 7"]
    Aggregates["Protein aggregates"]
    Transcription["Transcriptional dysregulation"]
    Photoreceptors["Photoreceptor degeneration"]
    Cerebellum["Cerebellar degeneration"]
    Retina["Retinal degeneration"]
    VisualLoss["Progressive vision loss"]
    Ataxia["Progressive ataxia"]
    HDAC["Histone deacetylases"]
    Autophagy["Autophagy dysfunction"]
    Apoptosis["Neuronal apoptosis"]
    Neurodegeneration["Neurodegeneration"]

    ATXN7 -->|"expands"| PolyQ
    PolyQ -->|"produces"| MutATXN7
    MutATXN7 -->|"disrupts"| SAGA
    MutATXN7 -->|"forms"| Aggregates
    SAGA -->|"regulates"| Transcription
    Transcription -->|"affects"| Photoreceptors
    Transcription -->|"affects"| Cerebellum
    MutATXN7 -->|"causes"| SCA7
    Aggregates -->|"impairs"| Autophagy
    Aggregates -->|"activates"| Apoptosis
    SCA7 -->|"damages"| Retina
    SCA7 -->|"damages"| Cerebellum
    Retina -->|"leads to"| VisualLoss
    Cerebellum -->|"leads to"| Ataxia
    Autophagy -->|"promotes"| Neurodegeneration
    Apoptosis -->|"causes"| Neurodegeneration

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff

    class ATXN7 central
    class PolyQ,MutATXN7,Aggregates,Transcription,Autophagy,Apoptosis,Photoreceptors,Cerebellum,Retina pathological
    class SCA7,VisualLoss,Ataxia,Neurodegeneration disease
    class SAGA,HDAC regulatory