Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Autophagy Failure: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Amyloid-β Accumulation | contributes_to | phenotype | 0.90 |
| NEURONS | heightens_vulnerability | cell_type | 0.80 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, a | 0.776 | multi | Cross-disease neurodegeneration mechanis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089] | Quinn PMJ, Moreira PI, Ambrósio AF, Alve | Acta neuropathologica communic | 2020 | 0 |
| Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. [PMID:25803835] | Unknown | Nature neuroscience | 2015 | 0 |
| The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. [PMID:25611507] | ["Pickrell Alicia M", "Youle Richard J"] | Neuron | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Autophagy Failure in their description or question text
No additional research found