gene

BAG4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAG4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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0Debates

Summary

Page for BAG4

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🧬 Gene Info

Gene Symbol	BAG4
Chromosome	8p11.21
Protein Type	Chaperone
Function	is a member of the BAG family of co-chaperones that modulate the activity of Hsp70/Hsc70 heat shock proteins.
Amino Acids	110 aa
Ensembl ID	ENSG00000140650
GeneCards	BAG4
Human Protein Atlas	BAG4
Hsp70 Co-chaperone Activity	Binds to Hsp70 ATPase domain, modulating its chaperone cycle
Anti-apoptotic Function	Inhibits apoptosis through multiple mechanisms
Protein Quality Control	Facilitates refolding and clearance of damaged proteins
Tumor Suppressor Activity	Frequently downregulated in cancers, suggesting tumor suppressive function
[HSP70 family](/proteins/hsp70-protein)	Hsp70/Hsc70 ATP-dependent chaperone
[HSP40 family](/proteins/hsp40-protein)	Hsp40 co-chapERones that stimulate Hsp70 ATPase
[HSP90 family](/entities/hsp90-protein)	Hsp90 chaperone complex
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BAG4

gene · 936 words

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Pathway Diagram

graph TD
    BAG4["BAG4"]
    style BAG4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    neurodegeneration["neurodegeneration"]

    BAG4 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class neurodegeneration disease

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAG4 in their description or question text

No additional research found