Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BBB Permeability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | risk_factor_for | disease | 0.90 |
| Bbb Disruption | associated_with | phenotype | 0.90 |
| Neuronal Damage | biomarker_for | phenotype | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 34248961 | increase | paper | 0.90 |
| 39427196 | acutely increased | paper | 0.90 |
| Claudin-5 | modulates | protein | 0.70 |
| tight junction complexes | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circulating Endothelial Microvesicles Expressing Degraded Cl | 0.640 | - | What blood-brain barrier permeability ch |
| IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability | 0.397 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.735
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.73 · 2026-04-25
closed · Rounds: 4 · Score: 0.63 · 2026-04-22
Hypotheses and analyses mentioning BBB Permeability in their description or question text
No additional research found