entity

MMP-9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP-9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

7Hypotheses

2Analyses

5Outgoing

7Incoming

0Experiments

2Debates

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Wiki Pages (1)

Knowledge base pages for this entity

MMP-9 Inhibitors for Neurodegeneration

therapeutic · 506 words

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Outgoing (5)

Target	Relation	Type	Str
OCLN	proteolytically_cleaves	protein	0.00
TJP1	proteolytically_cleaves	protein	0.00
BBB integrity loss	regulates	mechanism	0.70
BBB integrity	inhibits	process	0.50
CLDN5	proteolytically_cleaves	protein	0.25

Incoming (7)

Source	Relation	Type	Str
30458231	is expressed only by	paper	0.90
30458231	expressed by	paper	0.90
16481424	is required for	paper	0.90
THBS1	correlates_with	protein	0.80
16481424	modulates	paper	0.60
16481424	localizes to	paper	0.60
30458231	is expressed by	paper	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho	0.711	ALS	What are the mechanisms by which microgl
CCL2-CCR2 Driven Macrophage Infiltration Selectively Strips	0.682	ALS	CCL2-CCR2 Axis at NMJ: Mechanism of Sele
SASP-Secreted MMP-9 from Senescent Microglia Disrupts TDP-43	0.525	ALS	What are the mechanisms by which microgl
TBK1 Loss Drives Microglial Senescence-SASP to Generate MMP-	0.525	ALS	What are the mechanisms by which microgl
HTR2A-Mediated MMP-9 Suppression Preserves BBB Integrity at	0.425	-	What is the minimum effective dose of tr

SASP-Secreted MMP-9 from Senescent Microglia Disrupts Nuclea	0.389	ALS	What are the mechanisms by which microgl
TBK1 Loss Drives MMP-9-Mediated TDP-43 Fragmentation Through	0.386	ALS	What are the mechanisms by which microgl

Mentioning Analyses (2)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.735

What is the optimal therapeutic window for microglial reprogramming before irrev

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.735

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells. [PMID:41000837]	Unknown	bioRxiv	2025	0
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology a [PMID:36201573]	Unknown	Science	2022	0
Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopat [PMID:34412701]	Unknown	Acta Neuropathol Commun	2021	0
Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP- [PMID:30458231]	Unknown	Neurobiology of disease	2019	0
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and i [PMID:30146158]	Xu D, Jin T, Zhu H, Chen H, Ofengeim D,	Cell	2018	0
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synaps [PMID:28669544]	Unknown	Neuron	2017	0

Debates (2)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Multiple hypotheses assumed microglia could be restored to homeostatic states, b

closed · Rounds: 4 · Score: 0.63 · 2026-04-22

Related Research

Hypotheses and analyses mentioning MMP-9 in their description or question text

SASP-Secreted MMP-9 from Senescent Microglia Disrupts Nuclear-Cytoplasmic Transp

Score: 0.389 · ALS · 2026-04-26

This hypothesis proposes that MMP-9 secreted by senescent microglia in the SASP drives ALS pathology through disruption

TBK1 Loss Drives MMP-9-Mediated TDP-43 Fragmentation Through Senescent Microglia

Score: 0.386 · ALS · 2026-04-26

TBK1 deficiency in microglia creates a pathological cascade that directly generates ALS-driving TDP-43 pathology through