Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BMF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | BMF |
| Full Name | Bcl-2 Modifying Factor |
| Chromosome | 15q14 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues with highest expression in: |
| Subcellular Localization | Release from cytoskeletal sequestration is a key regulatory step |
| Amino Acids | 184 aa |
| UniProt ID | [Q9Y3T5](https://www.uniprot.org/uniprot/Q9Y3T5) |
| Ensembl ID | ENSG00000108298 |
| GeneCards | BMF |
| Human Protein Atlas | BMF |
| BH3 Domain | The critical Bcl-2 Homology 3 domain (amino acids 112-135) is essential for pro-apoptotic function. This amphipathic α-helix mediates interactions with anti-apoptotic Bcl-2 family members. |
| N-terminal Region | Contains regulatory sequences including a serine-rich region that can be phosphorylated. |
| C-terminal Tail | Hydrophobic region involved in membrane localization. |
| p53-dependent transcription | BMF can be transcriptionally activated by p53 in response to DNA damage |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BMF["BMF"]
neurodegeneration["neurodegeneration"]
BMF -->|"implicated_in"| neurodegeneration
style BMF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BMF in their description or question text
No additional research found