gene

BRSK1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about BRSK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for BRSK1 Gene

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🧬 Gene Info

Gene Symbol	BRSK1
Full Name	Brain-Specific Serine/Threonine-Protein Kinase 1
Chromosome	19q13.42
Protein Type	Serine/Threonine Kinase
Function	BRSK1 is a brain-enriched serine/threonine kinase essential for neuronal polarization and axon specification
Subcellular Localization	Calcium regulation — BRSK1 activity may be modulated by calcium-dependent signaling in neurons
Pathways	AMPK
UniProt ID	Q8TDC3
NCBI Gene ID	84446
Ensembl ID	ENSG00000160469
OMIM	609235
GeneCards	BRSK1
Human Protein Atlas	BRSK1
Axon determination	BRSK1 is activated by LKB1/STK11 at the nascent axon tip; its local activation triggers the symmetry-breaking event that converts one neurite into the axon
SAD kinase function	In C. elegans, the SAD-1 ortholog clusters synaptic vesicles at presynaptic terminals; mammalian BRSK1 retains this function while gaining additional polarity roles
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BRSK1 — AlphaFold Q8TDC3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BRSK1 Gene

gene · 1422 words

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Pathway Diagram

graph TD
    BRSK1["BRSK1"]
    neurodegeneration["neurodegeneration"]
    BRSK1 -->|"implicated_in"| neurodegeneration
    style BRSK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning BRSK1 in their description or question text

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