Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BUB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | BUB1 |
| Protein Type | Kinase |
| Function | is a serine/threonine-protein kinase that plays a critical role in the mitotic checkpoint (spindle assembly checkpoint), ensuring proper chromosome segregation during cell division[@yu2007]. |
| Primary Expression | proliferating cells: - Highest: Bone marrow, testis, embryonic tissues[@gtex] - Cell cycle-regulated: Peak in G2/M phase - Low/undetectable: Most diff |
| Subcellular Localization | and activity[@ruchaud2007] BUB1 contains: - N-terminal kinetochore-targeting do |
| GeneCards | BUB1 |
| Human Protein Atlas | BUB1 |
| Checkpoint signaling | BUB1 phosphorylates MAD3/BUBR1 to generate the mitotic checkpoint complex (MCC)[@chen1999] |
| Kinetochore localization | BUB1 localizes to kinetochores and recruits other checkpoint proteins[@sharpbaker2001] |
| Chromosome alignment | Ensures proper kinetochore-microtubule attachments[@li2009] |
| Centromere function | Regulates Aurora B kinase localization and activity[@ruchaud2007] |
| Colorectal cancer | BUB1 mutations in microsatellite instability-high tumors[@shichiri2002] |
| Breast cancer | Altered expression in aggressive subtypes[@yuan2006] |
| Hematologic malignancies | Mutations in B-cell lymphomas and leukemias[@cai2009] |
| Mosaic Variegated Aneuploidy (MVA) | Biallelic BUB1 mutations cause MVA syndrome[@matsuura2006] |
| Associated Diseases | ALS |
| Interactions | CDK1, MKI67, MMP1, MMP9, PLK1 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["BUB1"]
N1["ALS"]
N0 -->|"associated with"| N1
N2["CDK1"]
N0 -->|"co expressed with"| N2
N3["MMP1"]
N0 -->|"co expressed with"| N3
N4["ADRA2A"]
N4 -->|"co expressed with"| N0
N5["neurodegeneration"]
N0 -->|"implicated in"| N5
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene| Source | Relation | Type | Str |
|---|---|---|---|
| ADRA2A | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||