gene

MMP9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1730Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

MMP9 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALI, ALS, AMI. Connected to 884 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP9
Full Name	Matrix Metallopeptidase 9
Chromosome	20q12-13
Protein Family	Matrix metalloproteinase family ( gelatinase B)
Protein Type	Protease
Target Class	Protease
Function	Small molecule zinc-chelating inhibitors or antibody-based inhibition
Mechanism of Action	Small molecule zinc-chelating inhibitors or antibody-based inhibition
Primary Expression	Secreted, extracellular space, neutrophil granules
Druggability	Medium (0.54)
Clinical Stage	Phase III
Molecular Weight	92 kDa (pro-MMP9), 82 kDa (active)
Amino Acids	20 aa
Pathways	Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle
UniProt ID	P14780
NCBI Gene ID	4313
Ensembl ID	ENSG00000100985
OMIM	120361
GeneCards	MMP9
Human Protein Atlas	MMP9
Associated Diseases	ALI, ALS, AMI, Aging, Alzheimer
Known Drugs/Compounds	GENISTEIN, MMP9_IN1, IRN, Andrographis paniculata, MMP9-IN-1, Ginsenoside Rg2
Interactions	MMP2, TRKB, TNF, TLR4, CD68, MTOR
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	1730 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: MMP9 — PDB 1GKC Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    MMP9(["MMP9"])
    Inflammation["Inflammation"]
    Als["Als"]
    Aging["Aging"]
    Coronary_Artery_Disease["Coronary Artery Disease"]
    Luteolin["Luteolin"]
    neutrophil_extracellular_traps("neutrophil extracellular traps")
    necroptosis("necroptosis")
    autophagy("autophagy")
    h_1acdd55e["h-1acdd55e"]
    MMP9_IN_1{"MMP9-IN-1"}
    GATA4(["GATA4"])
    Akt_Mtor["Akt/Mtor"]
    Mapk["Mapk"]

    MMP9 -->|"therapeutic target"| Inflammation
    MMP9 -->|"activates"| Als
    MMP9 -->|"therapeutic target"| Als
    MMP9 -->|"therapeutic target"| Aging
    MMP9 -->|"biomarker for"| Coronary_Artery_Disease
    Luteolin -.->|"downregulates"| MMP9
    MMP9 -->|"participates in"| neutrophil_extracellular_traps
    MMP9 -->|"associated with"| necroptosis
    MMP9 -.->|"inhibits"| autophagy
    h_1acdd55e -->|"therapeutic target"| MMP9
    MMP9_IN_1 -.->|"inhibits"| MMP9
    GATA4 -.->|"inhibits"| MMP9
    Akt_Mtor -->|"upregulates"| MMP9
    h_1acdd55e -->|"targets gene"| MMP9
    MMP9 -->|"therapeutic target"| Mapk

    style MMP9 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1086)

Target	Relation	Type	Str
Inflammation	therapeutic_target	disease	1.00
extracellular matrix degradation	mediates	process	0.95
Als	activates	disease	0.95
Als	therapeutic_target	disease	0.95
Aging	therapeutic_target	disease	0.95
Coronary Artery Disease	biomarker_for	disease	0.95
neutrophil extracellular traps	participates_in	phenotype	0.90
autophagy	inhibits	phenotype	0.90
glycocalyx	degrades	process	0.90
cell migration	promotes	process	0.90
necroptosis	associated_with	phenotype	0.90
AKT	therapeutic_target	gene	0.90
Mapk	therapeutic_target	pathway	0.90
Autophagy	activates	pathway	0.90
Cell Metastasis	involved_in	process	0.85
Bone Loss	involved_in	phenotype	0.85
Brain Edema	associated_with	phenotype	0.85
Blood-Brain Barrier Integrity	associated_with	phenotype	0.85
vascular barrier integrity	suppresses	phenotype	0.85
Cell Migration	promotes	process	0.85
Cancer	inhibits	disease	0.85
Cancer	activates	disease	0.85
Cancer	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Breast Cancer	biomarker_for	disease	0.85
acute-on-chronic liver failure	associated_with	disease	0.80
mortality	contributes_to	phenotype	0.80
AQP4	inhibits	protein	0.80
Type 2 Diabetes Mellitus	biomarker_for	disease	0.80
Blood-Brain Barrier Function	associated_with	process	0.80
Non-Small-Cell Lung Cancer	involved_in	disease	0.80
neural stem cells	regulates	cell_type	0.80
neural stem cells	interacts_with	cell_type	0.80
NLRP3	activates	protein	0.80
extracellular matrix	remodels	structure	0.80
Apoptosis	activates	pathway	0.80
INFLAMMATION	therapeutic_target	gene	0.80
APOPTOSIS	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
CANCER	activates	gene	0.80
CANCER	inhibits	gene	0.80
Metastasis	therapeutic_target	pathway	0.80
Tumor	activates	disease	0.75
Parkinson	therapeutic_target	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Fibrosis	biomarker_for	disease	0.75
Als	associated_with	disease	0.75
Tumor	inhibits	disease	0.75
Tumor	therapeutic_target	disease	0.75
Fibrosis	therapeutic_target	disease	0.75

Incoming (644)

Source	Relation	Type	Str
Luteolin	downregulates	compound	0.95
MMP9-IN-1	inhibits	drug	0.90
GATA4	inhibits	protein	0.90
Akt/Mtor	upregulates	pathway	0.90
Timp-1	inhibits	protein	0.90
MMP2	co_mentioned_with	gene	0.90
Hu-Loaded Exosomes	downregulates	compound	0.90
HB147	downregulates	compound	0.90
Litebamine	downregulates	compound	0.90
h-1acdd55e	targets_gene	hypothesis	0.90
TNF	therapeutic_target	gene	0.90
GENES	therapeutic_target	gene	0.90
H3K27Ac	regulates	biomarker	0.85
H3K56Ac	regulates	biomarker	0.85
Genistein	binds	compound	0.85
AKT/MTOR Signaling Pathway	upregulates	pathway	0.85
NFKB1	upregulates	protein	0.85
IL1B	upregulates	protein	0.85
cardamom nanoemulsion	downregulates	compound	0.85
FB23	downregulates	drug	0.85
CURCUMIN	targets	drug	0.85
IL-6	associated_with	gene	0.82
UVB	contributes_to	drug	0.80
Andrographis paniculata	inhibits	drug	0.80
p65	activates	protein	0.80
h-1acdd55e	targets	hypothesis	0.80
NDRG2	upregulates	gene	0.80
TNF	upregulates	pathway	0.80
C9ORF72	upregulates	gene	0.80
Qingqi Liangying formula	downregulates	drug	0.80
AKT1	therapeutic_target	gene	0.80
MMP2	inhibits	gene	0.80
PI3K	therapeutic_target	gene	0.80
IL-6	interacts_with	protein	0.80
GENES	implicated_in	gene	0.80
INFLAMMATION	activates	gene	0.80
TNF	associated_with	gene	0.74
IL-1B	associated_with	gene	0.74
STAT3	regulates	protein	0.72
MMP9_IN1	inhibits	drug	0.72
IRN	inhibits	drug	0.72
OSTEOCLASTS	expressed_in	cell_type	0.72
LUTEOLIN	regulates	drug	0.72
IL1B	therapeutic_target	gene	0.70
TLR4	activates	gene	0.70
IL6	activates	gene	0.70
PTGS2	expressed_in	gene	0.70
CD169+ perivascular macrophages	regulates	cell_type	0.70
Ginsenoside Rg2	inhibits	drug	0.70
MyD88	activates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MMP9

Understanding Entity Pages

Summary

Wiki Pages (21)

MMP9 Gene

amyloid-beta-metalloproteinases

blood-brain-barrier

neurovascular-coupling

bbb-transport-mechanisms

cGAS-STING Signaling in Parkinson's Disease

Stress Granule Dysfunction Hypothesis in Parkinson's Disease

Neurovascular Unit Dysfunction Hypothesis in Parkinson's Disease

Section 253: Respiratory Function and Dysphagia Therapy in CBS/PSP

Necroptosis in Neurodegeneration

Blood-Brain Barrier Breakdown as Primary Disease Driver

Gilead Sciences

pericyte-dysfunction

ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

RAB32 Gene

HTR3C Gene

MECP2 — Methyl-CpG Binding Protein 2

MMP9 Protein

KDR Gene