| Gene Symbol | KNL1 |
| Protein Type | Scaffold Protein |
| Function | is a fundamental kinetochore scaffold protein that links microtubules to centromeric chromatin and activates the spindle assembly checkpoint[@cheeseman2006]. |
| Primary Expression | proliferating cells:
- High expression: Bone marrow, testis, embryonic tissues
- Cell cycle-regulated: Peak in G2/M phase[@obrien2015]
- Low in non-di |
| GeneCards | KNL1 |
| Human Protein Atlas | KNL1 |
| Microtubule attachment | KNL1 recruits the NDC80 and MIS12 complexes to form a functional kinetochore[@deluca2006] |
| Spindle checkpoint activation | BUB1 and BUBR1 phosphorylate KNL1 to generate checkpoint signals[@london2012] |
| Chromatin binding | Direct interaction with CENP-A nucleosomes at centromeres[@nishino2013] |
| Spindly recruitment | Recruits the dynein/dynactin complex for checkpoint silencing[@barisic2014] |
| Multiple cancers | KNL1 overexpression in aggressive tumors[@singh2014] |
| Chromosomal instability | KNL1 dysfunction leads to aneuploidy[@holland2014] |
| Therapeutic target | Potential for anti-mitotic therapy[@bakhoum2009] |
| Alzheimer's disease | Kinetochore dysfunction contributes to neuronal aneuploidy[@yang2001] |
| Aging | Age-related decline in kinetochore function[@baker2014] |
| Associated Diseases | Als, Cancer, Carcinoma |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |