gene

MMP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

233Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MMP1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 97 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP1
Full Name	Matrix Metalloproteinase 1
Aliases	Page for MMP1
Protein Type	Enzyme
Function	MMP1 (Matrix Metallopeptidase 1), also known as interstitial collagenase, is a zinc-dependent endopeptidase that degrades native collagen types I, II, and III.
Pathways	TGF-β
Ensembl ID	ENSG00000196611
GeneCards	MMP1
Human Protein Atlas	MMP1
Extracellular Matrix Degradation	MMP1 cleaves collagen I, II, III, gelatin, and other matrix proteins. This activity is essential for tissue remodeling during development, wound healing, and injury response.
Inflammatory Signaling	MMP1 releases bioactive fragments from matrix proteins that act as chemotactic signals for immune cells. It activates pro-inflammatory cytokines and modulates immune responses.
Amyloid Processing	MMP1 can degrade Aβ peptides and may contribute to amyloid clearance in the brain. However, dysregulated MMP1 activity can also generate toxic fragments.
Growth Factor Activation	MMP1 releases and activates growth factors from the extracellular matrix, including TGF-β, influencing cell proliferation and differentiation.
Associated Diseases	ALS, Cancer, Fibrosis, Senescence, neuroinflammation, oxidative stress
Known Drugs/Compounds	icariin
Interactions	FER, MMP3, SLC7A11, SOX9, PKC, MMP9
KG Connections	233 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MMP1["MMP1"]
    MMP1 -->|"inhibits"| TIMP1["TIMP1"]
    MMP1 -->|"inhibits"| TIMP2["TIMP2"]
    MMP1 -->|"degrades"| Collagen_IV["Collagen IV"]
    MMP1 -->|"degrades"| Collagen["Collagen"]
    MMP1 -->|"degrades"| Collagen_I["Collagen I"]
    MMP1 -.biomarker for.-> Breast_cancer["Breast cancer"]
    MMP1 -->|"activates"| NR1a_NR2B["NR1a/NR2B"]
    MMP1 -->|"upregulates"| Perforin["Perforin"]
    MMP1 -->|"upregulates"| m_NOS["m-NOS"]
    MMP1 -->|"upregulates"| COX_2["COX-2"]
    AP_1["AP-1"] -->|"upregulates"| MMP1
    NF__B["NF-kappaB"] -->|"upregulates"| MMP1
    FAS["FAS"] -->|"target for"| MMP1
    MMP3["MMP3"] -->|"activates"| MMP1
    GPX4["GPX4"] -->|"activates"| MMP1
    SOX9["SOX9"] -->|"activates"| MMP1
    SLC7A11["SLC7A11"] -->|"activates"| MMP1
    GENES["GENES"] -->|"regulates"| MMP1
    FER["FER"] -->|"activates"| MMP1
    BAK1["BAK1"] -->|"regulates"| MMP1

Outgoing (162)

Target	Relation	Type	Str
TIMP1	inhibits	protein	0.80
TIMP2	inhibits	protein	0.80
Collagen IV	degrades	protein	0.80
Collagen I	degrades	protein	0.80
Breast cancer	biomarker_for	disease	0.80
Collagen	degrades	protein	0.80
NR1a/NR2B	activates	receptor	0.70
Perforin	upregulates	protein	0.70
m-NOS	upregulates	enzyme	0.70
COX-2	upregulates	enzyme	0.70
Cartilage	degrades	entity	0.70
oxidative stress response	participates_in	pathway	0.70
Arthritis	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Senescence	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Obesity	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Als	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Diabetes	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Senescence	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Autoimmune	inhibits	disease	0.65
BAK1	regulates	gene	0.60
BCL2L1	regulates	gene	0.60
FER	activates	gene	0.60
MMP3	activates	gene	0.60
SLC7A11	inhibits	gene	0.60

Incoming (71)

Source	Relation	Type	Str
FAS	therapeutic_target	gene	0.60
MMP3	activates	gene	0.60
GPX4	activates	gene	0.60
SOX9	activates	gene	0.60
SLC7A11	activates	gene	0.60
FER	activates	gene	0.60
BAK1	regulates	gene	0.60
BCL2L1	regulates	gene	0.60
FER	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
MMP9	activates	gene	0.60
CD4	biomarker_for	gene	0.60
MMP7	associated_with	gene	0.60
CD4	associated_with	gene	0.60
FAS	associated_with	gene	0.60
FAS	treats	entity	0.60
NOS1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
SERPINA3	associated_with	gene	0.60
PRDX6	interacts_with	gene	0.60
MT1A	interacts_with	gene	0.60
CD44	associated_with	gene	0.60
SOD1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
MMP9	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CRYAB	associated_with	gene	0.60
IL6	associated_with	gene	0.60
IL6	activates	gene	0.60
GDF15	interacts_with	gene	0.60
BUB1	activates	gene	0.60
CDK1	activates	gene	0.60
MKI67	activates	gene	0.60
CCL25	associated_with	gene	0.60
CNP	associated_with	gene	0.60
GENES	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
P16INK4A	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
P21CIP1	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
ROS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
P53	activates	gene	0.60
AGING	regulates	gene	0.60
BRAIN INJURY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MMP1

Understanding Entity Pages

Summary

Wiki Pages (12)

MMP1 - Matrix Metallopeptidase 1

TNFAIP6 — TNF Alpha Induced Protein 6 (TSG-6)

IL17B Gene

IL26 Gene

CCL25 Gene

MMP7 - Matrix Metallopeptidase 7

MT1A (Metallothionein-1A)

IL17A — Interleukin 17A

MMP3 Gene

BUB1