gene

CDK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

340Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page on CDK1, cell cycle kinase essential for G2/M transition, and its role in neuronal cell cycle re-entry and neurodegeneration in Alzheimer's and Parkinson's diseases

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🧬 Gene Info

Gene Symbol	CDK1
Full Name	Cyclin-Dependent Kinase 1
Chromosome	10q21.1
Protein Type	Kinase
Function	is a gene located on chromosome 10q21.
Primary Expression	Ubiquitous (neurons, glia, proliferating cells)
Molecular Weight	34 kDa
Amino Acids	297 aa
Pathways	Angiogenesis, Autophagy, Cell Cycle, Differentiation, Epigenetic
UniProt ID	P06493
NCBI Gene ID	983
Ensembl ID	ENSG00000164946
OMIM	176741
GeneCards	CDK1
Human Protein Atlas	CDK1
Associated Diseases	ALS, Cancer, Inflammation
Known Drugs/Compounds	rapamycin
Interactions	BECN1, APP, TAU, CDK5, CDK2, PIEZO1
KG Connections	340 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDK1 — AlphaFold P06493 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDK1["CDK1"]
    CDK1 -->|"phosphorylates"| TP53["TP53"]
    CDK1 -->|"inhibits"| BECN1["BECN1"]
    CDK1 -->|"regulates"| CAPN6["CAPN6"]
    CDK1 -->|"regulates"| Als["Als"]
    CDK1 -->|"target for"| Senescence["Senescence"]
    CDK1 -->|"target for"| Ms["Ms"]
    CDK1 -->|"target for"| Tumor["Tumor"]
    CDK1 -->|"activates"| Glioma["Glioma"]
    BMAL1["BMAL1"] -->|"activates"| CDK1
    GENES["GENES"] -->|"activates"| CDK1
    CCNA1["CCNA1"] -->|"activates"| CDK1
    BRAF["BRAF"] -->|"target for"| CDK1
    ARNT["ARNT"] -->|"regulates"| CDK1
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| CDK1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"inhibits"| CDK1
    BAX["BAX"] -->|"expressed in"| CDK1
    AGING["AGING"] -->|"target for"| CDK1
    DOCK2["DOCK2"] -->|"target for"| CDK1

Outgoing (215)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Oncogene-Induced Senescence	involved_in	process	0.85
TP53	phosphorylates	protein	0.80
Tumor	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Cancer	activates	disease	0.75
Aging	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Tumor	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
BECN1	inhibits	gene	0.70
CAPN6	regulates	protein	0.70
AKT	regulates	gene	0.70
CANCER	regulates	gene	0.70
Mapk	regulates	pathway	0.70
Als	regulates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioma	activates	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Inflammation	associated_with	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Ms	regulates	disease	0.65
Aging	regulates	disease	0.65
ALS	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	activates	disease	0.65
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ARNT	regulates	gene	0.60

Incoming (125)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
BMAL1	upregulates	protein	0.90
XHP	downregulates	drug	0.90
BMAL1	binds	gene	0.85
PI3K	regulates	gene	0.70
GENES	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
BMAL1	activates	gene	0.64
BRAF	therapeutic_target	gene	0.60
ARNT	regulates	gene	0.60
BAX	expressed_in	gene	0.60
DOCK2	therapeutic_target	gene	0.60
MFN1	regulates	gene	0.60
MSH6	activates	gene	0.60
CLOCK	regulates	gene	0.60
BRAF	regulates	gene	0.60
CDK6	therapeutic_target	gene	0.60
CDK2	regulates	gene	0.60
CDK4	therapeutic_target	gene	0.60
PLK1	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
FTH1	activates	gene	0.60
UBE2N	activates	gene	0.60
TAK1	causes	gene	0.60
CDK2	activates	gene	0.60
EGFR	expressed_in	gene	0.60
GBM	expressed_in	gene	0.60
HSP90B1	activates	gene	0.60
EGFR	activates	gene	0.60
HSPA4	activates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
PRKACB	activates	gene	0.60
PIK3R1	activates	gene	0.60
IGF1	activates	gene	0.60
EGFR	therapeutic_target	gene	0.60
CYCLIN B1	activates	gene	0.60
CDK5	activates	gene	0.60
APP	inhibits	gene	0.60
TAU	inhibits	gene	0.60
MYC	regulates	gene	0.60
PLK1	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
NOS3	contributes_to	gene	0.60
DNMT1	contributes_to	gene	0.60
HDAC6	contributes_to	gene	0.60
EGFR	interacts_with	gene	0.60
CHEK1	interacts_with	gene	0.60
CDK2	interacts_with	gene	0.60
ALDH2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CDK1

Understanding Entity Pages

Summary

Wiki Pages (21)

CDK1 — Cyclin-Dependent Kinase 1

mitochondrial-dynamics

Mitochondrial Dynamics Dysfunction Hypothesis in Parkinson's Disease

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

Cyclin E2 (CCNE2) Protein

Mitochondrial Fission in Neurodegeneration

E2F7 Gene

KIF18A Gene — Kinesin Family Member 18A

WEE1 Protein (WEE1 Kinase)

CDK11 — Cyclin-Dependent Kinase 11

KIF14 Gene

CDC25C — Cell Division Cycle 25C

Mitochondrial Dynamics Pathway: Fusion and Fission in Neurodegeneration

MCL1 Gene - Myeloid Cell Leukemia 1

stathmin

Mitochondrial Dynamics in Neurodegeneration

CHEK2 — Checkpoint Kinase 2

KIF4A — Kinesin Family Member 4A

Vimentin - Biomarker