Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MKI67: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| High-Grade Serous Ovarian Cancer | biomarker_for | disease | 0.85 |
| MTOR | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| PIK3CA | activates | gene | 0.60 |
| PSMA1 | activates | gene | 0.60 |
| PSMB5 | activates | gene | 0.60 |
| RPS6KB1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| TCF4 | activates | gene | 0.60 |
| cancer | activates | disease | 0.60 |
| NFKB1 | targets | gene | 0.60 |
| NLRP3 | targets | gene | 0.60 |
| TLR4 | targets | gene | 0.60 |
| NEFH | associated_with | gene | 0.60 |
| NEFL | associated_with | gene | 0.60 |
| PVALB | associated_with | gene | 0.60 |
| SST | associated_with | gene | 0.60 |
| TPR | associated_with | gene | 0.60 |
| PVALB | interacts_with | gene | 0.60 |
| SST | interacts_with | gene | 0.60 |
| MMP1 | activates | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| PLK1 | activates | gene | 0.60 |
| PCNA | activates | gene | 0.60 |
| SMAD | activates | gene | 0.60 |
| TGFB | activates | gene | 0.60 |
| Alzheimer's disease | activates | disease | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| senescence | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| RAS | activates | gene | 0.60 |
| TSPAN1 | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| RNA | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:MKI67 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT | activates | gene | 0.60 |
| CDKN1A | activates | gene | 0.60 |
| CDKN2A | activates | gene | 0.60 |
| EIF4EBP1 | activates | gene | 0.60 |
| GLB1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| APC | activates | gene | 0.60 |
| AXIN2 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| CTNNB1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| AKT1 | targets | gene | 0.60 |
| CASP1 | targets | gene | 0.60 |
| IL1B | targets | gene | 0.60 |
| AURKB | associated_with | gene | 0.60 |
| CALM1 | associated_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| GAP43 | associated_with | gene | 0.60 |
| KIF15 | associated_with | gene | 0.60 |
| KIF5B | associated_with | gene | 0.60 |
| AURKB | interacts_with | gene | 0.60 |
| CALM1 | interacts_with | gene | 0.60 |
| KIF5B | interacts_with | gene | 0.60 |
| BUB1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| DMSO | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| AMPK | activates | gene | 0.60 |
| CCND1 | activates | gene | 0.60 |
| CSNK1A1 | activates | gene | 0.60 |
| FAM83A | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| MIR454 | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:MKI67 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||