gene

C8A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about C8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for C8A

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🧬 Gene Info

Gene Symbol	C8A
Chromosome	1p31.3
Function	The C8 alpha chain functions as
Amino Acids	579 aa
Ensembl ID	ENSG00000157216
GeneCards	C8A
Human Protein Atlas	C8A
C8 Deficiency	Individuals with C8 deficiency have increased susceptibility to Neisseria infections, particularly Neisseria meningitidis
Recurrent Infections	Lack of functional MAC leads to impaired bacterial killing
MAC-mediated Injury	Sublytic MAC formation can contribute to neuronal injury in various neurodegenerative conditions
Glial Activation	MAC deposition may activate glial cells and contribute to neuroinflammation
Liver	Primary site of synthesis (hepatocytes)
Brain	Low baseline expression in astrocytes and microglia
Various tissues	Widely expressed at low levels
Diagnostic Markers	C8 levels can be measured for complement deficiency workup
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    C8A["C8A"]
    neurodegeneration["neurodegeneration"]
    C8A -->|"implicated_in"| neurodegeneration
    style C8A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning C8A in their description or question text

No additional research found

C8A