concept

CA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

385Connections

5Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

CA1 is a concept in neurodegeneration research. Key relationships include: co discussed, protects against, interacts with. Associated with DEPRESSION. Connected to 16 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	Hippocampal CA1 Pyramidal Neurons
Summary	Cell Type: Hippocampal CA1 Pyramidal Neurons
Key Genes/Proteins	TAU, GABRA1, AMYLOID, APP
Related Diseases	iron enrichment, selective vulnerability to neurodegeneration, hippocampal sclerosis, SYNAPTIC PLASTICITY, CHOLESTEROL
Linked Hypotheses	13 hypotheses

🔮 Predicted Structure: CA1 — AlphaFold P00915 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CA1["CA1"]
    ketamine["ketamine"] -->|"activates"| CA1
    ABCA1["ABCA1"] -->|"expressed in"| CA1
    MTOR["MTOR"] -->|"expressed in"| CA1
    P62["P62"] -->|"expressed in"| CA1
    LC3["LC3"] -->|"expressed in"| CA1
    APOE["APOE"] -->|"expressed in"| CA1
    SQSTM1["SQSTM1"] -->|"expressed in"| CA1
    LDL["LDL"] -->|"expressed in"| CA1
    AMPK["AMPK"] -->|"expressed in"| CA1
    ACTB["ACTB"] -->|"expressed in"| CA1

Outgoing (61)

Target	Relation	Type	Str
iron enrichment	associated_with	phenotype	0.95
selective vulnerability to neurodegeneration	associated_with	phenotype	0.90
hippocampal sclerosis	associated_with	phenotype	0.80
SYNAPTIC PLASTICITY	regulates	phenotype	0.70
TAU	treats	protein	0.70
CHOLESTEROL	regulates	phenotype	0.70
SYNAPTIC PLASTICITY	treats	phenotype	0.70
AGING	interacts_with	phenotype	0.70
AGING	causes	phenotype	0.70
MICROGLIA	expressed_in	cell_type	0.65
MICROGLIA	degrades	cell_type	0.65
NEURODEGENERATION	activates	disease	0.65
NEURON	degrades	cell_type	0.65
NEURONS	degrades	cell_type	0.65
NLRP3	degrades	gene	0.65
HIPPOCAMPUS	exacerbates	brain_region	0.65
LOCUS COERULEUS	exacerbates	brain_region	0.65
GABAERGIC	inhibits	cell_type	0.65
GLUTAMATERGIC	inhibits	cell_type	0.65
NEURON	increases	cell_type	0.65
NEURONS	increases	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
METFORMIN	protects_against	drug	0.65
DEPRESSION	activates	disease	0.65
TAU	interacts_with	gene	0.65
MICROGLIA	impairs	cell_type	0.65
PSD95	regulates	gene	0.65
DENTATE GYRUS	regulates	brain_region	0.65
ENTORHINAL CORTEX	inhibits	brain_region	0.65
TAU	inhibits	gene	0.65
AGING	biomarker_for	phenotype	0.65
GFAP	protects_against	gene	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
PYRAMIDAL	protects_against	cell_type	0.60
NEURON	interacts_with	cell_type	0.60
NEURONS	interacts_with	cell_type	0.60
MICROGLIA	causes	cell_type	0.60
INTERNEURON	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
MICROGLIA	inhibits	cell_type	0.60
P2RX7	inhibits	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
ROS	associated_with	phenotype	0.50
METFORMIN	associated_with	drug	0.45
TAU	associated_with	protein	0.45
CORTEX	co_discussed	brain_region	0.40
CX3CR1	co_discussed	gene	0.40
STRIATUM	co_discussed	brain_region	0.40

Incoming (324)

Source	Relation	Type	Str
pyramidal neurons	expressed_in	cell_type	1.00
ketamine	activates	drug	0.70
GABRA1	phosphorylates	gene	0.70
AMYLOID	regulates	protein	0.70
AMYLOID	treats	protein	0.70
APP	stabilizes	gene	0.70
TAU	protects_against	protein	0.70
NEURON	treats	cell_type	0.70
CORTEX	causes	brain_region	0.70
CA3	regulates	brain_region	0.70
ISCHEMIA	activates	disease	0.70
HDAC3	inhibits	gene	0.70
AMYLOID-BETA	exacerbates	gene	0.65
ASTROCYTE	impairs	cell_type	0.65
LACTATE	activates	phenotype	0.65
SYNAPTIC PLASTICITY	causes	phenotype	0.65
KETAMINE	regulates	drug	0.65
ACHE	protects_against	gene	0.60
ASTROCYTE	causes	cell_type	0.60
ASTROCYTES	exacerbates	cell_type	0.60
ASTROCYTE	inhibits	cell_type	0.60
ASTROCYTES	inhibits	cell_type	0.60
BDNF	protects_against	gene	0.60
HDAC3	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	targets	disease	0.60
KETAMINE	expressed_in	drug	0.55
APP	associated_with	gene	0.50
GABRA1	associated_with	gene	0.50
CHOLESTEROL	associated_with	phenotype	0.50
ABCA1	associated_with	gene	0.50
NMDAR	associated_with	gene	0.50
APOE	associated_with	gene	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
HK2	associated_with	gene	0.50
LRP1	associated_with	gene	0.50
PHOSPHO-TAU	associated_with	protein	0.50
SYNAPTIC TRANSMISSION	associated_with	phenotype	0.50
COGNITIVE DECLINE	associated_with	phenotype	0.50
NEUROGENESIS	associated_with	phenotype	0.50
HDAC3	associated_with	gene	0.50
PARP1	associated_with	gene	0.50
BRCA1	associated_with	gene	0.50
DLG4	associated_with	gene	0.50
BRD4	associated_with	gene	0.50
ATM	associated_with	gene	0.50
TET2	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
AMYLOID PLAQUES	associated_with	phenotype	0.50
GRANULE CELLS	associated_with	cell_type	0.50
INTERNEURONS	associated_with	cell_type	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.695	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu	0.470	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
Repurposing of doxycycline as a novel therapeutic avenue for management of parki [PMID:41925933]	Ali NH, Al-Kuraishy HM, Hussain NR, Al-G	Inflammopharmacology	2026	0
Histological findings in follow-up liver biopsies up to 15 years after pediatric [PMID:41370831]	Quintero-Bernabeu J, Salcedo-Allende MT,	Liver Transpl	2026	0
Protein Corona Reprograms Hepatic Clearance Pathways of Biomimetic Nanoparticles [PMID:41944292]	He T, Fang X, Zhu L, Fan H, Qiu Y et al.	Small	2026	0
Mid-Term Comparison of N-Butyl Cyanoacrylate, Endovenous Laser Ablation, and Rad [PMID:41964281]	Dilek I, Kocaoglu AS, Büyükceran EU, Nay	Vasc Endovascular Surg	2026	0
Knee Osteoarthritis as a Causal Risk Factor for Parkinson's Disease: Converging [PMID:41925436]	Peng Z, Wang G	The American journal of geriat	2026	0
Reactive astrocyte subpopulations with high Gfap and C4b expression in different [PMID:41837502]	Huang C, Han Y, He J, Ma W, Chen Y, Dong	Neural regeneration research	2026	0
Longitudinal investigation of the T helper (Th)1-Th2 balance and complement syst [PMID:41872173]	Zhang T, Zhao J, Tang X, Wei Y, Ju M, Zh	Translational psychiatry	2026	0
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914]	Liu R, Wu Z, Yin Y, Song C, Zhang C et a	J Ethnopharmacol	2026	0
Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634]	Yoon S, Chun E, Iqbal H, Kim SH, Kim SY	J Ethnopharmacol	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0

CA1

Understanding Entity Pages

Summary

Wiki Pages (21)

Hippocampal CA1 Pyramidal Neurons

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Corticobasal Degeneration (CBD)

CBS/PSP Treatment Rankings

GRIA3 Gene

nct07165106

NTF4 Protein

HNRNPA2B1 Protein

CNTN5 — Contactin 5

Growth Factor Therapies

CLCN10 — Chloride Voltage-Gated Channel 10

ncam2

amyloid-beta-metalloproteinases

gabaergic-dysfunction

CNTN6 — Contactin 6

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

dendritic-spines