Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CACNG1 gene encoding the gamma-1 subunit of voltage-gated calcium channels, with roles in calcium homeostasis and neurodegenerative disease
| Gene Symbol | CACNG1 |
| Aliases | Page for CACNG1 Protein |
| Chromosome | 17q24 |
| Function | Cacng1 Protein Calcium Channel Gamma 1 Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, ... |
| Molecular Weight | 33 kDa |
| Amino Acids | 270 aa |
| Ensembl ID | ENSG00000096433 |
| GeneCards | CACNG1 |
| Human Protein Atlas | CACNG1 |
| First transmembrane domain (TM1) | Contributes to channel subunit interaction interface |
| Second transmembrane domain (TM2) | Forms the core of the channel pore (with gamma-1 specifically) |
| Third transmembrane domain (TM3) | Involves subunit-subunit contacts |
| Fourth transmembrane domain (TM4) | Participates in membrane-spanning region |
| Loop regions | Major extracellular loop between TM1 and TM2 contains N-linked glycosylation sites |
| C-terminal tail | Intracellular domain involved in protein-protein interactions and modulation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CACNG1["CACNG1"]
neurodegeneration["neurodegeneration"]
CACNG1 -->|"implicated_in"| neurodegeneration
style CACNG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||