gene 1,590 words KG: CACNG1
Contents

CACNG1 Gene - Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1

🧬 Gene Info
Gene SymbolCACNG1
AliasesPage for CACNG1 Protein
Chromosome17q24
FunctionCacng1 Protein Calcium Channel Gamma 1 Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, ...
Molecular Weight33 kDa
Amino Acids270 aa
Ensembl IDENSG00000096433
GeneCardsCACNG1
Human Protein AtlasCACNG1
First transmembrane domain (TM1)Contributes to channel subunit interaction interface
Second transmembrane domain (TM2)Forms the core of the channel pore (with gamma-1 specifically)
Third transmembrane domain (TM3)Involves subunit-subunit contacts
Fourth transmembrane domain (TM4)Participates in membrane-spanning region
Loop regionsMajor extracellular loop between TM1 and TM2 contains N-linked glycosylation sites
C-terminal tailIntracellular domain involved in protein-protein interactions and modulation
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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