gene

CACNG8

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CACNG8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CACNG8

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🧬 Gene Info

Gene Symbol	CACNG8
Chromosome	11q13.1
Function	### Synaptic Transmission
Primary Expression	the hippocampus and cerebral cortex, where it plays crucial roles in synaptic transmission, lea
Amino Acids	322 aa
Exons	14
Ensembl ID	ENSG00000167528
GeneCards	CACNG8
Human Protein Atlas	CACNG8
AMPA receptor regulation	TARP γ8 dramatically slows deactivation and desensitization kinetics of AMPA receptors, prolonging synaptic currents[@kraft2016]
Trafficking	TARP γ8 is required for proper delivery of AMPA receptors to synaptic sites during development and plasticity
gating modulation	TARP γ8 stabilizes the open state of AMPA receptors, enhancing synaptic efficacy
Impaired AMPA receptor regulation	Reduced TARP γ8 expression in AD hippocampus correlates with synaptic failure[@tarps2009]
Calcium dysregulation	Altered calcium channel function affects synaptic plasticity
Memory deficits	TARP γ8-dependent mechanisms are essential for hippocampal memory consolidation
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNG8

gene · 1806 words

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Pathway Diagram

graph TD
    CACNG8["CACNG8"]
    neurodegeneration["neurodegeneration"]
    CACNG8 -->|"implicated_in"| neurodegeneration
    style CACNG8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CACNG8 in their description or question text

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