protein

CAMK1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMK1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The kinase is activated by binding of calcium/calmodulin to its regulatory domain, which relieves autoinhibition and allows substrate phosphorylation[@hook2001].

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🔬 Protein Info

Gene Symbol	CAMK1PROTEIN
Protein Type	Kinase
Function	is a serine/threonine protein kinase that plays critical roles in neuronal signaling, synaptic plasticity, and memory formation.
Primary Expression	various tissues
Subcellular Localization	kinase is activated by binding of calcium/calmodulin to its regulatory domain, w
Molecular Weight	42 kDa
Amino Acids	374 aa
GeneCards	CAMK1PROTEIN
Human Protein Atlas	CAMK1PROTEIN
CaMK1-alpha	Predominant neuronal isoform
CaMK1-beta	Expressed in various tissues
CaMK1-gamma	Testis-specific variant
Phosphorylation of Synaptic Proteins	Phosphorylates proteins involved in synaptic vesicle release and neurotransmitter release[@skelding2011]
AMPA Receptor Regulation	Modulates AMPA receptor trafficking and function during long-term potentiation (LTP)
NMDA Receptor Modulation	Regulates NMDA receptor channel properties and downstream signaling
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CaMK1 Protein

protein · 970 words

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Pathway Diagram

graph TD
    CAMK1PROTEIN["CAMK1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CAMK1PROTEIN -->|"implicated_in"| neurodegeneration
    style CAMK1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CAMK1PROTEIN in their description or question text

No additional research found