Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAPSN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CAPSN1 |
| Function | Calsyntenin-1 (also known as Alcadein-beta or CAPSN1) is a neuronal membrane protein belonging to the cadherin superfamily. |
| Primary Expression | neurons and is localized to synaptic membranes |
| Subcellular Localization | synaptic membranes |
| Molecular Weight | 110 kDa |
| Amino Acids | 3000 aa |
| UniProt ID | Q9BQP5 |
| NCBI Gene ID | 27245 |
| Ensembl ID | ENSG00000171530 |
| GeneCards | CAPSN1 |
| Human Protein Atlas | CAPSN1 |
| Amyotrophic Lateral Sclerosis (ALS) | Altered CAPSN1 expression has been reported in ALS motor neurons. |
| Schizophrenia | CAPSN1 genetic variants have been associated with schizophrenia risk. |
| N-terminal signal peptide | Targets protein to secretory pathway |
| Extracellular domain | Contains 10 cadherin repeats, ~3000 amino acids |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CAPSN1["CAPSN1"]
ICE1["ICE1"]
CAPSN1 -->|"interacts with"| ICE1
neurodegeneration["neurodegeneration"]
CAPSN1 -->|"implicated in"| neurodegeneration
style CAPSN1 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity