protein

CATHEPSINL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSINL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	CATHEPSINL
Full Name	Cathepsin L
Protein Family	Papain family (C1A)
Protein Type	Protease
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	33 kDa (proenzyme), 25 kDa (mature enzyme)
UniProt ID	P07711
GeneCards	CATHEPSINL
Human Protein Atlas	CATHEPSINL
Signal peptide	Targets the protein to the secretory pathway
Propeptide	Inhibits activity until reaching the lysosome
Mature enzyme	Active protease following propeptide cleavage
Active site	Catalytic cysteine (C25), histidine (H163), and asparagine (N183)
Occluding loop	Regulates substrate access
Two disulfide bonds	Stabilize the structure
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CATHEPSINL — AlphaFold P07711 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cathepsin L Protein

protein · 582 words

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Pathway Diagram

graph TD
    CATHEPSINL["CATHEPSINL"]
    neurodegeneration["neurodegeneration"]
    CATHEPSINL -->|"implicated_in"| neurodegeneration
    style CATHEPSINL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CATHEPSINL in their description or question text

No additional research found