Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCNL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CCNL1 |
| Aliases | Cyclin L1 gene |
| Function | The CCNL1 gene encodes Cyclin L1, a 646-amino acid protein |
| Primary Expression | human tissues with highest expression in brain, heart, and testis |
| Subcellular Localization | s and functions. Expression is regulated during cell cycle and in response to cellular stress |
| Amino Acids | 646 aa |
| UniProt ID | CCNL1 |
| Ensembl ID | ENSG00000132359 |
| GeneCards | CCNL1 |
| Human Protein Atlas | CCNL1 |
| Pre-mRNA Splicing | Essential component of the spliceosome, regulating both constitutive and alternative splicing. |
| Transcriptional Regulation | Partners with CDK11 to phosphorylate RNA polymerase II and transcriptional co-activators. |
| Alternative Splicing | The RS domain allows interaction with splicing factors to modulate splice site selection. |
| Cell Cycle Control | Regulates G2/M transition through phosphorylation of cell cycle targets. |
| Cancer | CCNL1 overexpression in various cancers including lung, breast, and ovarian cancers. Promotes tumor growth through enhanced splicing of oncogenic isoforms. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["CCNL1"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CCNL1 in their description or question text
No additional research found