Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CFI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CFI |
| Chromosome | 4p25.3 |
| Protein Type | Protease |
| Function | C3b Cleavage: Factor I cleaves C3b at specific sites, generating inactive C3b (iC3b) |
| Primary Expression | various tissues including the brain |
| Amino Acids | 406 aa |
| Ensembl ID | ENSG00000167644 |
| GeneCards | CFI |
| Human Protein Atlas | CFI |
| Glomerulonephritis | CFI mutations associated with renal disease |
| Infection Susceptibility | Particularly with encapsulated bacteria |
| Liver | Primary site of synthesis (hepatocytes) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CFI["CFI"]
neurodegeneration["neurodegeneration"]
CFI -->|"implicated_in"| neurodegeneration
style CFI fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CFI in their description or question text
No additional research found