Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHCHD5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHCHD5 encodes a mitochondrial protein involved in oxidative phosphorylation, complex I activity, and neuronal survival. Implicated in Parkinson's disease and ALS through mitochondrial dysfunction.
| Gene Symbol | CHCHD5 |
| Full Name | Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5 |
| Chromosome | 2q31.1 |
| Function | is a small mitochondrial protein that plays essential roles in oxidative phosphorylation, cellular respiration, and neuronal survival. |
| Primary Expression | Mitochondrial (inner membrane/IMS) |
| Molecular Weight | ~12 kDa |
| Amino Acids | 112 aa |
| UniProt ID | Q8N5Z0 |
| NCBI Gene ID | 130560 |
| Ensembl ID | ENSG00000182809 |
| OMIM | — |
| GeneCards | CHCHD5 |
| Human Protein Atlas | CHCHD5 |
| Encoded Protein | CHCHD5 |
| Protein Length | 112 amino acids |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHCHD5["CHCHD5"]
neurodegeneration["neurodegeneration"]
CHCHD5 -->|"implicated_in"| neurodegeneration
style CHCHD5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||