gene 1,844 words KG: CHCHD5 2026-03-27
kind:genesection:genesstate:published
Contents

CHCHD5 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5

🧬 Gene Info
Gene SymbolCHCHD5
Full NameCoiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5
Chromosome2q31.1
Functionis a small mitochondrial protein that plays essential roles in oxidative phosphorylation, cellular respiration, and neuronal survival.
Primary ExpressionMitochondrial (inner membrane/IMS)
Molecular Weight~12 kDa
Amino Acids112 aa
UniProt IDQ8N5Z0
NCBI Gene ID130560
Ensembl IDENSG00000182809
OMIM
GeneCardsCHCHD5
Human Protein AtlasCHCHD5
Encoded ProteinCHCHD5
Protein Length112 amino acids
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in