gene

CHRM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CHRM2 — Muscarinic Acetylcholine Receptor M2

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🧬 Gene Info

Gene Symbol	CHRM2
Full Name	Muscarinic Acetylcholine Receptor M2
Protein Type	Receptor
Function	The Muscarinic Acetylcholine Receptor M2 (CHRM2) is a G protein-coupled receptor (GPCR) that mediates the effects of acetylcholine on slow inhibitory postsynaptic potentials in the heart, smooth muscl
Primary Expression	the hippocampus, cerebral cortex, and basal ganglia, where it modulates learning, memory, and r
Ensembl ID	ENSG00000131617
GeneCards	CHRM2
Human Protein Atlas	CHRM2
Hippocampus	highest in CA3 region and dentate gyrus
Cerebral cortex	layers II-III and V-VI
Basal ganglia	striatum and globus pallidus
Thalamus	relay nuclei
Heart	atrial and ventricular myocardium
Smooth muscle	gastrointestinal tract, bladder
Xanomeline	M1/M4 preferring agonist, investigated for AD
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CHRM2 — Muscarinic Acetylcholine Receptor M2

gene · 636 words

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Muscarinic Acetylcholine Receptor M2 (CHRM2)

protein · 755 words

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Pathway Diagram

graph TD
    CHRM2["CHRM2"]
    neurodegeneration["neurodegeneration"]
    CHRM2 -->|"implicated_in"| neurodegeneration
    style CHRM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CHRM2 in their description or question text

No additional research found