gene

CHRNA10

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CHRNA10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CHRNA10 (Cholinergic Receptor Nicotinic Alpha Subunit 10)

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🧬 Gene Info

Gene Symbol	CHRNA10
Aliases	Cholinergic Receptor Nicotinic Alpha Subunit 10
Chromosome	11p15.5
Protein Type	Channel
Function	is a pentameric ligand-gated ion channel that responds to acetylcholine and other cholinergic agonists.
Primary Expression	non-neuronal tissues and can form calcium-permeable channels
Ensembl ID	ENSG00000147434
GeneCards	CHRNA10
Human Protein Atlas	CHRNA10
Channel Type	Ligand-gated cation channel
Ion Permeability	Permeable to Na+, K+, and Ca2+
Activation	Acetylcholine, nicotine (partial agonist)
Pharmacology	Blocked by α-bungarotoxin and other conotoxins
Neuroinflammation	α9α10 nAChRs on immune cells may modulate microglial activation through the cholinergic anti-inflammatory pathway [@rosasballina2009]
Calcium dysregulation	The Ca2+-permeable nature of these receptors may contribute to calcium homeostasis alterations in AD
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHRNA10 (Cholinergic Receptor Nicotinic Alpha Subunit 10)

gene · 587 words

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Pathway Diagram

graph TD
    CHRNA10["CHRNA10"]
    neurodegeneration["neurodegeneration"]
    CHRNA10 -->|"implicated_in"| neurodegeneration
    style CHRNA10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CHRNA10 in their description or question text

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