| Gene Symbol | CHRNA10 |
| Aliases | Cholinergic Receptor Nicotinic Alpha Subunit 10 |
| Chromosome | 11p15.5 |
| Protein Type | Channel |
| Function | is a pentameric ligand-gated ion channel that responds to acetylcholine and other cholinergic agonists. |
| Primary Expression | non-neuronal tissues and can form calcium-permeable channels |
| Ensembl ID | ENSG00000147434 |
| GeneCards | CHRNA10 |
| Human Protein Atlas | CHRNA10 |
| Channel Type | Ligand-gated cation channel |
| Ion Permeability | Permeable to Na+, K+, and Ca2+ |
| Activation | Acetylcholine, nicotine (partial agonist) |
| Pharmacology | Blocked by α-bungarotoxin and other conotoxins |
| Neuroinflammation | α9α10 nAChRs on immune cells may modulate microglial activation through the cholinergic anti-inflammatory pathway [@rosasballina2009] |
| Calcium dysregulation | The Ca2+-permeable nature of these receptors may contribute to calcium homeostasis alterations in AD |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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