Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNA9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CHRNA9 |
| Full Name | Cholinergic Receptor Nicotinic Alpha Subunit 9 |
| Chromosome | 17p13.2 |
| Protein Family | Cys-loop nAChR family |
| Function | The CHRNA9 gene encodes a protein involved in critical cellular processes in the nervous system. |
| Primary Expression | outer hair cells of the cochlea |
| Subcellular Localization | </b></td><td>Plasma membrane (ion channel)</td></tr> [@wang2014] |
| UniProt ID | [Q9GZZ3](https://www.uniprot.org/uniprot/Q9GZZ3) |
| Ensembl ID | ENSG00000174373 |
| GeneCards | CHRNA9 |
| Human Protein Atlas | CHRNA9 |
| Extracellular N-terminal domain | Contains the characteristic Cys-loop motif and agonist binding sites |
| Intracellular loop | Contains sites for post-translational modifications and protein interactions |
| C-terminal domain | Involved in receptor assembly and trafficking |
| Dopaminergic neuron protection | α9* nAChRs on substantia nigra dopamine neurons provide neuroprotective signaling[@quik2015] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNA9["CHRNA9"]
neurodegeneration["neurodegeneration"]
CHRNA9 -->|"implicated_in"| neurodegeneration
style CHRNA9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHRNA9 in their description or question text
No additional research found