Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CHRNB1 |
| Aliases | Cholinergic Receptor Nicotinic Beta Subunit 1 |
| Chromosome | 17p13.1 |
| Protein Family | Cys-loop receptor superfamily |
| Function | Ligand-gated ion channel mediating fast synaptic transmission |
| Primary Expression | select brain regions including basal forebrain, hippocampus, and cortex[@counts2021] |
| GeneCards | CHRNB1 |
| Human Protein Atlas | CHRNB1 |
| Stoichiometry | α1₂β1δγ(ε) |
| Location | Motor endplates, autonomic ganglia, some CNS neurons |
| Ion flux | Permeable to Na⁺ and K⁺ (and Ca²⁺ to a lesser degree) |
| Fast synaptic transmission | Response latency of <1 ms |
| Desensitization | Prolonged agonist exposure leads to receptor inactivation |
| Allosteric modulation | Multiple binding sites for modulatory compounds |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNB1["CHRNB1"]
neurodegeneration["neurodegeneration"]
CHRNB1 -->|"implicated_in"| neurodegeneration
style CHRNB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHRNB1 in their description or question text
No additional research found