gene

CLCN10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive gene page for CLCN10, a voltage-gated chloride channel critical for renal acidification, osteoclast function, endosomal pH regulation, and neuronal chloride homeostasis. Mutations cause osteopetrosis with renal tubular acidosis.

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🧬 Gene Info

Gene Symbol	CLCN10
Full Name	Chloride Voltage-Gated Channel 10
Chromosome	12p13.31
Protein Family	CLC voltage-gated chloride channel family (CLCN1-7, CLCNKA, CLCNKB)
Function	is an integral membrane protein that functions primarily as a chloride channel or chloride-proton exchanger, depending on the specific isoform and cellular context.
Molecular Weight	89 kDa
Amino Acids	805 aa
Exons	26
UniProt ID	O75477 (CLCN10_HUMAN)
NCBI Gene ID	11253
Ensembl ID	ENSG00000113337
OMIM	600715
GeneCards	CLCN10
Human Protein Atlas	CLCN10
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLCN10 — AlphaFold O75477 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLCN10 — Chloride Voltage-Gated Channel 10

gene · 4939 words

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Pathway Diagram

graph TD
    CLCN10["CLCN10"]
    neurodegeneration["neurodegeneration"]
    CLCN10 -->|"implicated_in"| neurodegeneration
    style CLCN10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLCN10 in their description or question text

No additional research found