protein

CLCN4PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN4PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The crystal structure of ClC-4 has been solved (PDB: 6MGY), revealing a dimeric architecture similar to other CLC family members[@fischer2019].

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🔬 Protein Info

Gene Symbol	CLCN4PROTEIN
Full Name	ClC-4 Chloride Channel
Chromosome	Xp22.2
Protein Family	CLC chloride channel family
Protein Type	Channel
Function	is a voltage-gated chloride channel encoded by the CLCN4 gene.
Primary Expression	multiple tissues:
Subcellular Localization	Endosomes, plasma membrane
Molecular Weight	~85 kDa
Exons	12
UniProt ID	P51801
GeneCards	CLCN4PROTEIN
Human Protein Atlas	CLCN4PROTEIN
Protein Name	ClC-4 Chloride Channel
Gene	CLCN4
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CLCN4PROTEIN — AlphaFold P51801 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ClC-4 Chloride Channel

protein · 888 words

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Pathway Diagram

graph TD
    CLCN4PROTEIN["CLCN4PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CLCN4PROTEIN -->|"implicated_in"| neurodegeneration
    style CLCN4PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity