gene

CLSTN1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CLSTN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Calsyntenin 1

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🧬 Gene Info

Gene Symbol	CLSTN1
Full Name	Calsyntenin 1
Chromosome	1p36.21
Protein Type	Receptor
Function	It interacts with the amyloid precursor protein (APP) and may regulate amyloid-beta production.
Primary Expression	developing and mature neurons
UniProt ID	Q9BZZ5
NCBI Gene ID	64085
Ensembl ID	ENSG00000171603
OMIM	611295
GeneCards	CLSTN1
Human Protein Atlas	CLSTN1
CLSTN1	High expression in cortex, hippocampus, and cerebellum. Enriched in postsynaptic densities. 6
LGI1	Broad expression in brain, particularly hippocampus and cerebral cortex. Expressed in neurons and glia. 7
NRCAM	Expressed in developing nervous system, particularly in axon tracts. In adults, expression persists in specific brain regions. 8
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLSTN1 — AlphaFold Q9BZZ5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calsyntenin 1

gene · 929 words

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Pathway Diagram

graph TD
    CLSTN1["CLSTN1"]
    neurodegeneration["neurodegeneration"]
    CLSTN1 -->|"implicated_in"| neurodegeneration
    style CLSTN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CLSTN1 in their description or question text

No additional research found