gene

COA8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COA8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

COA8 gene page for mitochondrial disease

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🧬 Gene Info

Gene Symbol	COA8
Function	encodes a critical mitochondrial protein essential for the proper assembly and stability of cytochrome c oxidase (Complex IV) of the electron transport chain.
Molecular Weight	38 kDa
Amino Acids	358 aa
Ensembl ID	ENSG00000146233
GeneCards	COA8
Human Protein Atlas	COA8
Coiled-coil domains	residues 60-150, mediate protein-protein interactions with other assembly factors
Soluble intermembrane space domain	residues 150-300, the functional domain facing the intermembrane space where assembly occurs
Iron-sulfur binding motif	Cys-X3-Cys-X11-Cys motif (residues 310-325), potential 2Fe-2S cluster coordination important for electron transfer
Electron transfer	Cytochrome c → Cytochrome a/a3 complex
Proton pumping	Transfers protons across the inner mitochondrial membrane
Oxygen reduction	Reduces O₂ to H₂O as the final step of cellular respiration
ATP production	Complex IV drives the majority of proton pumping that creates the electrochemical gradient for ATP synthase
Oxygen consumption	Cytochrome c oxidase is the primary consumer of cellular oxygen (~90%)
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

COA8 Gene - Cytochrome c Oxidase Assembly Factor 8

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Genes

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Pathway Diagram

graph TD
    COA8["COA8"]
    neurodegeneration["neurodegeneration"]
    COA8 -->|"implicated_in"| neurodegeneration
    style COA8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found