| Gene Symbol | COA8 |
| Function | encodes a critical mitochondrial protein essential for the proper assembly and stability of cytochrome c oxidase (Complex IV) of the electron transport chain. |
| Molecular Weight | 38 kDa |
| Amino Acids | 358 aa |
| Ensembl ID | ENSG00000146233 |
| GeneCards | COA8 |
| Human Protein Atlas | COA8 |
| Coiled-coil domains | residues 60-150, mediate protein-protein interactions with other assembly factors |
| Soluble intermembrane space domain | residues 150-300, the functional domain facing the intermembrane space where assembly occurs |
| Iron-sulfur binding motif | Cys-X3-Cys-X11-Cys motif (residues 310-325), potential 2Fe-2S cluster coordination important for electron transfer |
| Electron transfer | Cytochrome c → Cytochrome a/a3 complex |
| Proton pumping | Transfers protons across the inner mitochondrial membrane |
| Oxygen reduction | Reduces O₂ to H₂O as the final step of cellular respiration |
| ATP production | Complex IV drives the majority of proton pumping that creates the electrochemical gradient for ATP synthase |
| Oxygen consumption | Cytochrome c oxidase is the primary consumer of cellular oxygen (~90%) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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