gene

COG2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about COG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for COG2 — Conserved Oligomeric Golgi Complex 2

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🧬 Gene Info

Gene Symbol	COG2
Full Name	Conserved Oligomeric Golgi Complex 2
Chromosome	1q25.2
Function	is a key component of the COG complex, a multi-subunit vesicle tethering apparatus essential for proper Golgi apparatus function and intracellular membrane trafficking.
Subcellular Localization	- Quality control of protein glycosylation - Proper sorting of proteins to their
Molecular Weight	182 kDa
GeneCards	COG2
Human Protein Atlas	COG2
Amyloid processing	Altered Golgi trafficking can affect amyloid precursor protein (APP) processing and amyloid-beta generation
[Tau](/proteins/tau) pathology	Impaired glycosylation may influence tau phosphorylation and aggregation
Synaptic dysfunction	Disrupted protein trafficking to synapses contributes to synaptic loss
Lysosomal function	COG2 deficiency impairs autophagosome-lysosome fusion, affecting protein clearance
Mitochondrial quality control	Proper trafficking is needed for mitochondrial protein import and turnover
Amyotrophic Lateral Sclerosis (ALS)	Disrupted protein homeostasis in motor neurons
Huntington's disease	Altered trafficking of mutant huntingtin protein
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

COG2 — Conserved Oligomeric Golgi Complex 2

gene · 638 words

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Pathway Diagram

graph TD
    COG2["COG2"]
    neurodegeneration["neurodegeneration"]
    COG2 -->|"implicated_in"| neurodegeneration
    style COG2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning COG2 in their description or question text

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